Distinct cDC subsets co-operate in CD40 agonist response while suppressive microenvironments and lack of antigens subvert efficacy
A. Murgaski, M. Kiss, H. Van Damme, D. Kancheva, I. Vanmeerbeek, J. Keirsse, E. Hadadi, J. Brughmans, S. M. Arnouk, A. E. I. Hamouda, A. Debraekeleer, V. Bosteels, Y. Elkrim, L. Boon, S. Hoves, , D. Laoui
This study identifies cDC subsets that cooperate in CD40 agonist response and shows that suppressive microenvironments and antigen scarcity limit its efficacy in cancer.
bioRxiv · Dec 25, 2021 · PreprintCancer Biology