L. Boon

Internal regulation between constitutively expressed T cell coinhibitory receptors BTLA and CD5 and tolerance in recent thymic emigrants

This study identifies a regulatory pathway between BTLA and CD5 in T cells that calibrates their expression to establish self-tolerance in recent thymic emigrants.

Trabectedin Enhances Oncolytic Virotherapy by Reducing Barriers to Virus Spread and Cytotoxic Immunity in Preclinical Pediatric Bone Sarcoma

This study shows trabectedin enhances oncolytic virotherapy by reducing anti-viral barriers and boosting immune-mediated tumor regression in preclinical models.

An Immunological Synapse Formation Between T Regulatory Cells and Cancer-Associated Fibroblasts Promotes Tumor Development

This study identifies an immunosuppressive mechanism in the tumor microenvironment where SMA+ cancer-associated fibroblasts process and present tumor antigens via autophagy to form immunological synapses with Foxp3+ T regulatory cells, promoting tumor development.

PD-L1 blockade immunotherapy rewires cancer emergency myelopoiesis

This study shows PD-L1 blockade in tumor-bearing mice targets bone marrow HSPCs, reprograms their transcriptome toward inflammation, and reduces myeloid-derived suppressor cells.

Mgl2+ cDC2s coordinate fungal allergic airway type 2, but not type 17, inflammation.

The paper identifies Mgl2+ cDC2s as key drivers of type 2, but not type 17, fungal allergic airway inflammation in mice.

Myeloid A20 is critical for type-2 immune mediated helminth resistance

This study identifies A20 as an essential myeloid factor for inducing type-2 immune responses against Trichuris muris, with its loss leading to chronic infection and inflammation.

An autophagy program that promotes T cell egress from the lymph node controls responses to immune checkpoint blockade

This study shows that autophagy in lymphatic endothelial cells controls T cell egress from lymph nodes, which is critical for immune checkpoint therapy effectiveness.

TUMOR ENDOTHELIAL CELL AUTOPHAGY IS A KEY VASCULAR-IMMUNE CHECKPOINT IN MELANOMA

This study shows that autophagy in tumor endothelial cells suppresses antitumor immunity in melanoma by promoting an immunosuppressive phenotype, and its inhibition enhances T cell infiltration and restricts tumor growth.

A lymph node-to-tumour PD-L1+macrophage circuit antagonizes dendritic cell immunotherapy

This paper shows that DC vaccines can activate PD-L1+ macrophages in lymph nodes and tumors, creating an immunosuppressive circuit that limits their effectiveness, but this can be overcome by combining with PD-L1 blockade.

Immune-mediated tumor control in the 5TGM1 transfer model of multiple myeloma

This study uses a murine model to show that C57Bl/6 mice can control multiple myeloma through IFN-gamma-dependent immune responses, highlighting the model's utility for studying anti-myeloma immunity.

A neutrophil-B-cell axis governs disease tolerance during sepsis via Cxcr4

This study identifies a neutrophil-B-cell axis that promotes disease tolerance during sepsis through Cxcr4 activation, reducing organ damage and immunothrombosis.

Distinct cDC subsets co-operate in CD40 agonist response while suppressive microenvironments and lack of antigens subvert efficacy

This study identifies cDC subsets that cooperate in CD40 agonist response and shows that suppressive microenvironments and antigen scarcity limit its efficacy in cancer.

Genotype and Th2 cells control monocyte to tissue resident macrophage differentiation during nematode infection of the pleural cavity

This study shows that host genetics and Th2 cells influence monocyte-to-tissue-resident-macrophage differentiation during nematode infection in mice.

ACE2 is the critical in vivo receptor for SARS-CoV-2 in a novel COVID-19 mouse model with TNF- and IFNγ-driven immunopathology

This paper develops a mouse-adapted SARS-CoV-2 strain, maVie16, to model COVID-19 in mice, showing that ACE2 is critical for disease and that blocking TNF/IFNγ reduces immunopathology.

Enteric glial cells favour accumulation of anti-inflammatory macrophages during the resolution of muscularis inflammation

This study identifies how enteric glial cells promote the differentiation of anti-inflammatory macrophages during muscularis inflammation resolution through CCL2 and CSF1 signaling.

Intestinal helminth infection transforms the CD4+ T cell composition of the skin

This study shows that intestinal helminth infection alters CD4+ T cell composition in the skin, leading to long-term changes in immune responses to antigens.

Cell-intrinsic IL4R alpha independence of large intestinal RELMα+ Ym1+ macrophages

This study shows that RELMα+ Ym1+ macrophages in the large intestine can upregulate these markers without IL4R signaling, challenging the idea that IL4/IL13 is required for their activation.

IL-17A both initiates (via IFNγ suppression) and limits the pulmonary type 2 immune response to nematode infection

This study shows IL-17A suppresses IFNγ to initiate and later limits type-2 immune responses in the lung during nematode infection.

Cross-protective immune responses induced by sequential influenza virus infection and by sequential vaccination with inactivated influenza vaccines

This study shows that sequential vaccination with inactivated influenza vaccines can reduce pandemic virus infection severity, while subunit vaccines cannot, through cross-reactive antibodies and CD8+ T cells.

Absence of surface IgD does not impair naive B cell homeostasis and memory B cell formation in humans

The paper shows that human B cells lacking surface IgD develop normally and form memory B cells without impairment.

Gelatinase B/matrix metalloproteinase-9 is a phase-specific effector molecule, independent from Fas, in experimental autoimmune encephalomyelitis

This study investigates the role of MMP-9 in EAE, showing it acts independently of Fas and has phase-specific effects on disease progression and immune activation.