BiochemistrybioRxiv
A PKA Inhibitor Motif within Smoothened Controls Hedgehog Signal Transduction
J. T. Happ, C. D. Arveseth, J. Bruystens…·B. R. Myers
This study identifies a PKA inhibitor motif in Smoothened that blocks PKA activity, enabling GLI activation in the Hedgehog pathway, revealing a mechanism similar to the Wnt cascade.
DOI 10.1038/s41594-022-00838-z