Author

D. Bertinetti

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

F. W. Herberg· 3 shared A. Dakwar· 1 shared A. Hoy· 1 shared B. R. Myers· 1 shared C. C. King· 1 shared C. D. Arveseth· 1 shared C. Fecher-Trost· 1 shared C. Olivieri· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersBiochemistry

F. W. Herberg

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Author profile →

3 papers

Recent·Most cited

Allosteric modulation of protein kinase A in individuals affected by NLPD-PKA , a neurodegenerative disease in which the RIβ-L50R variant is expressed

T. Benjamin-Zukerman, V. Pane, R. Safadi-Safa, M. Solomon, V. Lev-Ram, M. Aboraya, A. Dakwar, D. Bertinetti, A. Hoy, M. Mol, J. van Swieten, F. W. Herberg, R. Maillard, R. Ilouz

This study investigates the RIβ-L50R variant in NLPD-PKA, showing it causes misfolding, disrupts PKA holoenzyme assembly, and increases C-subunit nuclear translocation, with a potential therapeutic strategy to reduce dissociation.

bioRxiv · Jun 30, 2024 · PreprintCell Biology

Tripartite interactions of PKA catalytic subunit and C-terminal domains of cardiac Ca2+ channel modulate its β-adrenergic regulation

S. Oz, T. Sharon, S. Surbramaniam, T. Pallien, M. Katz, V. Tsemakhovich, D. R. Tripathy, G. Sasson, O. Chomsky-Hecht, L. Vysochek, M. Schulz, C. Fecher-Trost, K. Zuhlke, D. Bertinetti, F. W. Herberg, , N. Dascal

This study identifies direct interactions between PKA catalytic subunit and C-terminal domains of cardiac CaV1.2 channels, revealing their role in modulating β-adrenergic regulation.

bioRxiv · Nov 28, 2023 · PreprintBiochemistry

A PKA Inhibitor Motif within Smoothened Controls Hedgehog Signal Transduction

J. T. Happ, C. D. Arveseth, J. Bruystens, D. Bertinetti, I. B. Nelson, C. Olivieri, D. S. Hedeen, J.-F. Zhu, J. L. Capener, J. W. Bröckel, L. Vu, C. C. King, V. L. Ruiz-Perez, G. Veglia, F. W. Herberg, , B. R. Myers

This study identifies a PKA inhibitor motif in Smoothened that blocks PKA activity, enabling GLI activation in the Hedgehog pathway, revealing a mechanism similar to the Wnt cascade.

bioRxiv · Jul 5, 2021Biochemistry