PhysiologybioRxiv
Gi/o protein-coupled receptor inhibition of beta-cell electrical excitability and insulin secretion depends on Na+/K+ ATPase activation
M. T. Dickerson, P. K. Dadi, K. E. Zaborska…·D. A. Jacobson
This study shows that Gi/o-GPCR inhibition of beta-cell insulin secretion depends on Na+/K+ ATPase activation, which hyperpolarizes the membrane and modulates Ca2+ oscillations.