Author

D. A. Jacobson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 3 Cancer Biology· 1 Pathology· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:mouse· 4 Research Focus:host-pathogen & immune response· 3 Research Focus:cell signaling & trafficking· 2 Assay:electrophysiology· 2 Organism:human· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

P. K. Dadi· 3 shared A. Y. Nakhe· 2 shared J. R. Dobson· 2 shared M. T. Dickerson· 2 shared A. Coll· 1 shared A. Martinez-Sanchez· 1 shared A. Taler-Vercic· 1 shared A. Usenik· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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3 shared papersPhysiology

P. K. Dadi

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Author profile →

6 papers

Recent·Most cited

Purinergic Ca2+ signaling as a novel mechanism of drug tolerance in BRAF mutant melanoma

P. E. Stauffer, J. Brinkley, D. A. Jacobson, V. Quaranta, D. R. Tyson

This study identifies purinergic Ca2+ signaling via P2X7 receptors as a mechanism enabling drug tolerance in BRAF-mutant melanoma, with implications for overcoming treatment resistance.

bioRxiv · Nov 3, 2023Cancer Biology

The MODY-associated KCNK16 L114P mutation increases islet glucagon secretion and limits insulin secretion resulting in transient neonatal diabetes and glucose dyshomeostasis in adults

A. Y. Nakhe, P. K. Dadi, J. Kim, M. T. Dickerson, S. Behera, J. R. Dobson, S. Shrestha, J.-P. Cartailler, L. Sampson, M. A. Magnuson, D. A. Jacobson

This study shows that the KCNK16 L114P mutation causes neonatal diabetes and glucose dyshomeostasis in adult mice by disrupting islet insulin secretion and increasing glucagon secretion.

bioRxiv · Jun 20, 2023 · PreprintPhysiology

A mini-TGA protein, lacking a functional DNA-binding domain, modulates gene expression through heterogeneous association with transcription factors

S. Tomaz, M. Petek, T. Lukan, K. Pogacar, K. Stare, E. Teixeira Prates, D. A. Jacobson, J. Zrimec, G. Bajc, M. Butala, M. Pompe Novak, Q. M. Dudley, N. Patron, A. Taler-Vercic, A. Usenik, , K. Gruden

This study shows that a truncated TGA protein, lacking a DNA-binding domain, modulates gene expression by interacting with other TGA proteins and activating immune-related genes.

bioRxiv · Mar 30, 2022 · PreprintPlant Biology

Gi/o protein-coupled receptor inhibition of beta-cell electrical excitability and insulin secretion depends on Na+/K+ ATPase activation

M. T. Dickerson, P. K. Dadi, K. E. Zaborska, A. Y. Nakhe, C. M. Schaub, J. R. Dobson, N. M. Wright, J. C. Lynch, C. F. Scott, D. A. Jacobson

This study shows that Gi/o-GPCR inhibition of beta-cell insulin secretion depends on Na+/K+ ATPase activation, which hyperpolarizes the membrane and modulates Ca2+ oscillations.

bioRxiv · Feb 10, 2022Physiology

Antagonistic epistasis of Hnf4a and FoxO1 networks through enhancer interactionsin beta-cell function

T. Kuo, W. Du, Y. Miyachi, P. K. Dadi, D. A. Jacobson, D. Accili

The paper investigates the antagonistic epistasis between Hnf4a and FoxO1 networks in beta-cell function through enhancer interactions and gene expression analysis.

bioRxiv · Jul 4, 2020 · PreprintPathology

The mitochondrial Ca2+ uniporter MCU is required for normal glucose-stimulated insulin secretion in vitro and in vivo

E. Haythorne, E. Georgiadou, M. Dickerson, L. Lopez Noriega, T. J. Pullen, G. da Silva Xavier, S. Davis, A. Martinez-Sanchez, F. Semplici, R. Rizzuto, J. A. McGinty, P. M. French, M. C. Cane, D. A. Jacobson, I. Leclerc, G. A. Rutter

This study shows that the mitochondrial Ca2+ uniporter MCU is essential for normal glucose-stimulated insulin secretion in pancreatic beta-cells, both in vitro and in vivo.

bioRxiv · Sep 25, 2019Physiology