Author

J. Carmody

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Biology Disciplines

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Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:structural biology· 1

Frequent Co-Authors

B. Bolanos· 1 shared B. Bosbach· 1 shared B. Orris· 1 shared D. J. Shields· 1 shared J. T. Stivers· 1 shared K. W. Huynh· 1 shared M. Ammirati· 1 shared M. D. Petroski· 1 shared

Activity by Year

2022-2022 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 36 mutual co-author links

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1 shared paperBiochemistry

B. Bolanos

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1 paper

Recent·Most cited

Phosphorylation of SAMHD1 Thr592 increases C-terminal domain dynamics, tetramer dissociation, and ssDNA binding kinetics

B. Orris, K. W. Huynh, M. Ammirati, S. Han, B. Bolanos, J. Carmody, M. D. Petroski, B. Bosbach, D. J. Shields, J. T. Stivers

This study shows that phosphorylation of SAMHD1 at Thr592 increases tetramer dynamics and ssDNA binding, leading to rapid inactivation of dNTPase activity at stalled replication forks.

bioRxiv · Apr 5, 2022Biochemistry