S. Han

Targeting Neutrophil Extracellular Traps to inhibit Colon Cancer Tumor Necrosis and Metastasis

This study shows that neutrophil extracellular traps (NETs) drive tumor necrosis and metastasis in colorectal cancer, and inhibiting NET formation reduces necrosis and improves chemotherapy outcomes.

Pre-cancerous Niche Remodelling Dictates Nascent Tumour Survival

The paper shows that pre-cancerous niche remodeling by early tumour cells determines nascent tumour survival in mice.

Deep genetic substructure within bonobos

This paper identifies three genetically distinct bonobo populations with inferred geographic origins and estimates split times and effective population sizes, highlighting the need for conservation attention to substructure.

IGF2BP3 promotes the progression of gastric cancer by activating cGMP-PKG signaling pathway via targeting FBXO32

This study identifies IGF2BP3 as a promoter of gastric cancer progression by upregulating FBXO32 via m6A binding and activating the cGMP-PKG signaling pathway.

Structure-Based Design of a Highly Immunogenic, Conformationally Stabilized FimH Antigen for a Urinary Tract Infection Vaccine

The paper designs a conformationally stabilized FimH antigen for a UTI vaccine, showing improved immunogenicity and structural similarity to native FimH.

MEK1/2 and ERK1/2 mediated lung endothelial injury and altered hemostasis promote diffuse alveolar hemorrhage in murine lupus

This study shows that MEK1/2-ERK1/2 inhibition prevents diffuse alveolar hemorrhage in lupus-prone mice by reducing endothelial injury and restoring hemostasis.

Structural basis of the bacterial flagellar motor rotational switching

This study presents cryo-EM structures of the bacterial flagellar motor C ring in two rotational states, revealing the structural basis of directional switching.

Enhancing Agrobacterium-Mediated Soybean Transformation Efficiency with an Auxiliary Solution

This study improves soybean transformation efficiency using an auxiliary solution with Silwet L-77 and hormones, showing increased hairy root and hypocotyl transformation rates across varieties.

SHP-1 interacts with NFκB1 to inhibit its phosphorylation and nuclear translocation to suppress excessive bacterial inflammation

This study shows SHP-1 interacts with NFκB1 to inhibit its phosphorylation and nuclear translocation, thereby suppressing bacterial inflammation in Chinese tongue sole.

Structural basis for CCR6 modulation by allosteric antagonists

This paper presents two inactive CCR6 structures bound to allosteric antagonists, revealing structural insights into CCR6 inhibition and its implications for drug discovery.

Human spermatogonial stem cells retain states with a foetal-like signature

This study identifies a foetal-like state 0B in human spermatogonial stem cells that maintains a suppressive transcriptomic program, contrasting with rodent models where this state is not maintained into adulthood.

Peptide-based capture-and-release purification of extracellular vesicles and statistical algorithm enabled quality assessment

This paper introduces a peptide-based EV isolation method and a statistical algorithm to assess EV quality, showing improved identification of tumor markers in pancreatic cancer samples.

Tau P301L mutation promotes core 4R tauopathy fibril fold through near-surface water structuring and conformational rearrangement

This paper identifies a tau peptide fragment that forms seeding-competent fibrils and shows how the P301L mutation facilitates its aggregation into 4R tauopathy-like structures.

Somatic structural variants driving distinct modes of oncogenesis in melanoma

This study analyzes structural variants in melanoma subtypes, identifying distinct genomic properties and molecular drivers that may inform therapeutic strategies.

Pan-genome analysis of different morphotypes reveals genomic basis of Brassica oleracea domestication and differential organogenesis

This study constructs a pan-genome of Brassica oleracea to uncover genomic basis of domestication and organogenesis differences among morphotypes.

Guanine-containing ssDNA and RNA induce dimeric and tetrameric SAMHD1 in cryo-EM and binding studies

This study shows that guanine-containing ssDNA and RNA induce dimeric or tetrameric SAMHD1, with tetramers being inactive for dNTPase and RNase activity.

A mutation-mediated host shift drives Avian paramyxovirus type 1 evolution

This study identifies mutations in the P protein of Avian paramyxovirus type 1 that drive host shift from chickens to pigeons through enhanced degradation of LSm14A.

Mutations in tau protein promote aggregation by favoring extended conformations

This study investigates how specific tau mutations promote amyloid aggregation by altering conformational properties and intermolecular interactions.

MeCP2 binds to methylated DNA independently of phase separation and heterochromatin organisation

This paper shows MeCP2 binds methylated DNA without needing phase separation or heterochromatin, and its foci are rare in most mammals.

An inverse agonist of orphan receptor GPR61 reveals a novel allosteric mechanism

The paper reports the first structural characterization of GPR61 and identifies a potent inverse agonist, revealing an allosteric mechanism.

Selective effects of estradiol on human corneal endothelial cells

This study investigates how estradiol affects human corneal endothelial cells under different oxygen conditions, finding sex-specific effects on mitochondrial morphology and ATP levels.

Myostatin gene deletion alters gut microbiota stimulating fast-twitch glycolytic muscle growth

This study shows that Myostatin gene deletion in pigs alters gut microbiota, increasing SCFAs which stimulate fast-twitch glycolytic muscle growth through the Akt/mTOR pathway.

Analysis of evolutionary dynamics and clonal architecture in prostate cancer

This study analyzes prostate cancer clonal architecture and evolutionary dynamics in 845 tumors, finding that Black patients have more monoclonal tumors but higher recurrence rates, and identifies new mutational signatures linked to subclones.

An Empirical Study on the Motivation of Helping Behavior in Rats

This study investigates the motivations for helping behavior in rats through three experiments, finding that social contact and environmental interest are primary motivators, while distress alleviation and prior social experience influence behavior onset and persistence.

The AFB1 auxin receptor controls the cytoplasmic auxin response pathway in Arabidopsis thaliana

This study identifies the N-terminal region of AFB1 as critical for its specific role in the rapid auxin response pathway in Arabidopsis thaliana, including calcium influx and root growth inhibition.

Abnormal expression of Prolyl oligopeptidase (POP) and its catalytic products Ac-SDKP contributes to the ovarian fibrosis change in Polycystic ovary syndrome (PCOS) mice

This study shows that reduced Prolyl oligopeptidase (POP) and its product Ac-SDKP contribute to ovarian fibrosis in PCOS mice by altering MMP-2 and TGF-β1 expression.

Ghost admixture in eastern gorillas

The paper identifies archaic admixture in eastern gorillas using whole genome sequences and ABC with neural networks, finding introgression from a ghost lineage into their common ancestor.

IMPASTO: Multiplexed cyclic imaging without signal removal via self-supervised neural unmixing

IMPASTO enables erasureless cyclic imaging for multiplexed spatial proteomics through self-supervised neural unmixing, achieving 30-plex imaging with reduced tissue distortion.

Triggered functional dynamics of AsLOV2 by time-resolved electron paramagnetic resonance at high magnetic fields

The paper introduces TiGGER, a time-resolved EPR method at high magnetic fields, to study protein mechanical dynamics, finding that light activation causes rapid separation and slow relaxation in AsLOV2.

An Integrated Physiological, Cytology and Proteomics Reveals Network of Sugarcane Protoplasts Responses to Enzymolysis

The paper investigates sugarcane protoplast responses to enzymolysis using physiological, cytological, proteomic, and transcriptomic analyses, revealing changes in antioxidant activity, cell structure, and gene expression.