Loss of β-ketoacyl acyl carrier protein synthase III activity restores multidrug-resistant Escherichia coli sensitivity to previously ineffective antibiotics
Y. Hong, J. Qin, A. Verderosa, S. Hawas, B. Zhang, M. A. T. Blaskovich, J. Cronan, M. Totsika
This study shows that disrupting the FabH gene in E. coli reduces its resistance to antibiotics by compromising the cell envelope, making previously ineffective antibiotics effective again.
bioRxiv · Feb 18, 2022Microbiology