J. Qin

Blocker-SELEX: A Structure-guided Strategy for Developing Inhibitory Aptamers Disrupting Undruggable Transcription Factor Interactions

This paper introduces Blocker-SELEX, a structure-guided method to design inhibitory aptamers that disrupt transcription factor interactions, demonstrating efficacy against SCAF4/SCAF8-RNAP2 and WDR5-MYC complexes.

Determination and characterization of papillomaviurs and parvovirus causing mass mortality of Chinese tongue sole (Cynoglossus semilaevis) in China

This study identifies two novel viruses, CsPaV and CsPV, as the causative agents of mass mortality in farmed Chinese tongue sole, revealing their co-infection and potential for further research on viral interactions.

Determining glycosyltransferase functional order via lethality due to accumulated O-antigen intermediates, exemplified with Shigella flexneri O-antigen biosynthesis

The paper introduces a genetic approach to determine the functional order of glycosyltransferases in O-antigen biosynthesis using Shigella flexneri, identifying RfbG and RfbF as key enzymes in the assembly of the OAg repeating unit.

Proteomic Stratification of Prognosis and Treatment Options for Small Cell Lung Cancer

This study uses proteomic profiling to stratify small cell lung cancer into three subtypes with distinct clinical outcomes and treatment responses, identifying potential therapeutic targets and improving prognosis prediction.

Extensive diversity in Escherichia coli Group 3 capsules is driven by recombination and plasmid transfer from multiple species

The paper identifies seven new Group 3 capsule gene clusters in E. coli, revealing extensive diversity driven by recombination and plasmid transfer from multiple species.

O antigen biogenesis sensitises Escherichia coli K-12 to bile salts, a likely cause for how it lost its O antigen

This study shows that restoring O antigen in E. coli K-12 sensitizes it to bile salts and vancomycin, suggesting bile salts drove the loss of O antigen in K-12 strains.

Expansion of Disease Specific Cardiac Macrophages in Immune Checkpoint Inhibitor Myocarditis

This study identifies an inflammatory macrophage population expanded in ICI myocarditis, driven by IFN-γ signaling and T-cell interactions, suggesting IFN-γ blockade as a potential therapeutic strategy.

Bacterial suppressor-of-copper-sensitivity (Scs) proteins exhibit diverse thiol-disulfide oxidoreductase cellular functions

This study shows that ScsC proteins, despite structural differences, exhibit both dithiol oxidation and disulfide reduction activity, with oxidase activity dependent on environmental oxidation.

Splicing factor BUD31 promotes ovarian cancer progression through sustaining the expression of anti-apoptotic BCL2L12

This study identifies BUD31 as a splicing factor that promotes ovarian cancer by maintaining anti-apoptotic BCL2L12 expression through exon inclusion.

Cysteine dependent conformation heterogeneity of Shigella flexneri autotransporter IcsA and implications in its function

This paper investigates the role of cysteine residues in Shigella IcsA's conformational changes, showing how they influence adhesin activity and immune evasion.

Ploidy variation and spontaneous haploid-diploid switching of Candida glabrata clinical isolates

This study reports ploidy variation and spontaneous haploid-diploid switching in 500 clinical Candida glabrata isolates, revealing differences in morphology, antifungal susceptibility, virulence, and gene expression.

Loss of β-ketoacyl acyl carrier protein synthase III activity restores multidrug-resistant Escherichia coli sensitivity to previously ineffective antibiotics

This study shows that disrupting the FabH gene in E. coli reduces its resistance to antibiotics by compromising the cell envelope, making previously ineffective antibiotics effective again.

Structures of PKA-phospholamban complexes reveal a mechanism of familial dilated cardiomyopathy

This study reveals how PLN mutations reduce phosphorylation by altering conformation and PKA interactions, contributing to DCM.

SARS-CoV-2 causes human BBB injury and neuroinflammation indirectly in a linked organ chip platform

This study shows SARS-CoV-2 indirectly causes BBB injury and neuroinflammation through systemic inflammation, not direct viral infection, using a linked alveolus-BBB organ chip platform.

Identification of TAZ as the essential molecular switch in orchestrating SCLC phenotypic transition and metastasis

The paper identifies TAZ as a molecular switch driving phenotypic transition and metastasis in SCLC by analyzing mouse models and human data.

Lung adenocarcinoma cell-derived exosomal miR-328 promote osteoclastogenesis by targeting Nrp2

This study shows that exosomal miR-328 from lung adenocarcinoma cells promotes osteoclastogenesis by targeting Nrp2 and suggests its inhibitors as a potential treatment for bone metastasis.

Molecular basis for Ras suppressor-1 recruitment to focal adhesions and stabilization of consensus adhesome complex

This study determines the structural basis of Rsu-1 interaction with PINCH-1 and its role in forming a consensus adhesome complex essential for focal adhesion assembly.

A human disease model of SARS-CoV-2-induced lung injury and immune responses with a microengineered organ chip

This paper develops a microengineered lung organ chip model to study SARS-CoV-2-induced lung injury and immune responses, revealing distinct cellular responses and the role of immune cells in inflammation.

Quantifying phase separation property of chromatin associated proteins under physiological conditions using anti-1,6-hexanediol index

The paper quantifies the phase separation properties of chromatin-associated proteins using an anti-1,6-hexanediol index and shows functional correlations with chromatin organization.

An Engineered Genetic Circuit for Lactose Intolerance Alleviation Coupled with Gut Microbiota Recovery

This paper presents a genetic circuit that alleviates lactose intolerance by boosting beta-galactosidase activity and restoring gut microbiota through pH regulation in mice.

The transcriptional and splicing changes caused by hybridization can be globally recovered by genome doubling during allopolyploidization

This study shows that genome doubling in allopolyploids can recover transcriptional and splicing changes from hybridization, partially fixing heterosis and revealing new insights into transcriptome reprogramming mechanisms.

SUMOylation- and GAR1-dependent regulation of dyskerin nuclear and subnuclear localization

This study identifies SUMOylation sites in dyskerin that regulate its nuclear and subnuclear localization, essential for its function in telomerase and H/ACA ribonucleoprotein complexes.

Modeling SARS-CoV-2 infection in vitro with a human intestine-on-chip device

This paper develops an intestine-on-chip model to study SARS-CoV-2 infection, showing intestinal damage and immune response similar to human infection.

Rbx1 Cullin-Ring ligase E3 and Ube2m neddylation E2 differentially governs the fitness of Treg cells

This study shows Rbx1 and Ube2m differentially regulate Treg cell homeostasis and function, with Rbx1 deletion causing severe inflammation and Ube2m deletion causing milder issues, suggesting therapeutic potential for targeting neddylation/CRLs in immune disorders.

Rapid detection of SARS-CoV-2 and other respiratory viruses by using LAMP method with Nanopore Flongle workflow

This paper describes a rapid method using LAMP and Nanopore Flongle for detecting SARS-CoV-2 and other respiratory viruses in under two hours.

Global Screening of Sentrin-Specific Protease Family Substrates in SUMOylation

The paper identifies 3,763 SUMO1 modification sites and their dependence on six SENP proteins, revealing SENP3's role in innate immunity through deSUMOylation of DHX15 and PCBP2.

Mining the human tonsillar microbiota as autoimmune modulator

The paper identifies dysbiosis in RA tonsillar microbiota and shows that Streptococcus salivarius and its antibacterial peptides modulate autoimmunity by suppressing T cells and autoantibodies.

Branched-Chain Amino Acid Metabolic Reprogramming Orchestrates Drug Resistance to EGFR Tyrosine Kinase Inhibitors

This study identifies BCAT1-mediated metabolic reprogramming as a mechanism of EGFR TKI resistance in lung cancer and shows that combining TKI with ROS-inducing agents can overcome resistance.

The Role of the Public Health Service Equalization Program in the Control of Hypertension in China: Results from a Cross-sectional Health Interview Survey

This study evaluates the impact of China's Public Health Service Equalization Program on hypertension control using survey data, finding improved control rates and regional variability linked to administrative systems.

Mechanically Resolved Imaging of Bacteria using Expansion Microscopy

This paper introduces expansion microscopy to distinguish bacterial species and detect phenotypic changes in dense microbial communities.