B. Zhang

Vortex light field microscopy: 3D spectral single-molecule imaging with a twist

This paper introduces vortex light field microscopy, achieving 3D spectral single-molecule imaging with 25 nm spatial and 3 nm spectral precision.

Synchronous assembly of peptide anisosome

This study reports the formation of symmetrical core-shell biomolecular condensates through programmed tetra-peptide libraries and identifies tryptophan's role in structuring these condensates.

Melanization interacts with soil mineral and microbial properties to determine fungal carbon and nitrogen persistence in soils

This study shows that fungal melanin content and soil mineral properties interact to influence the formation of fungal-derived mineral-associated organic matter (MAOM) in soils.

Vaccine-elicited and naturally elicited antibodies differ in their recognition of the HIV-1 fusion peptide

This study compares vaccine-elicited and naturally elicited antibodies' recognition of HIV-1 fusion peptide sequences, finding that naturally elicited antibodies show greater tolerance to sequence variation.

The effects of L-carnitine and fructose in improved Ham's F10 on sperm culture in idiopathic severe asthenospermia within 24h

This study evaluates the effects of L-carnitine and fructose in modified Ham's F10 medium on sperm motility in idiopathic severe asthenospermia patients within 24h, finding improved viability at specific concentrations and temperature.

HIV-1 neutralizing antibodies in SHIV-infected macaques recapitulate structurally divergent modes of human V2 apex recognition with a single D gene

This study isolates and characterizes V2 apex-directed neutralizing antibodies from SHIV-infected macaques, revealing structural and genetic features that enable broad neutralization.

Two-hit mouse model of heart failure with preserved ejection fraction combining diet-induced obesity and renin-mediated hypertension

This paper develops a two-hit mouse model of HFpEF combining diet-induced obesity and renin-mediated hypertension, showing key features of the disease and response to therapy.

Coral hosts actively accumulate inorganic carbon for Symbiodiniaceae to maintain symbiotic relationships

This study shows corals actively accumulate dissolved inorganic carbon for their algal symbionts, supporting symbiosis, and reveals pathways involved in this process.

An anti-SARS-CoV-2 formula consisting volatile oil from TCM through inhibiting multiple targets in cultured cells

This paper develops a volatile oil formula from traditional Chinese medicine that inhibits SARS-CoV-2 by targeting multiple viral and host proteins in cultured cells.

Multi-omics reveals AKR1B1-regulated galactose metabolic as a driver of gastrointestinal stromal tumor progression

This study identifies AKR1B1-regulated galactose metabolism as a driver of gastrointestinal stromal tumor progression through multi-omics analysis.

Systematic analysis of gut bacterial carcinogen metabolism and its functional consequences

The paper systematically analyzes gut bacterial metabolism of carcinogens and shows bidirectional interactions with host metabolism, highlighting the microbiome's role in tumorigenesis.

Single-cell transcriptomics reveals immunosuppressive microenvironment and highlights stumor-promoting macrophage cells in Glioblastoma

This study uses single-cell transcriptomics to analyze GBM tumor microenvironment, identifying immunosuppressive macrophage subtypes and exhausted NK cells, suggesting therapeutic targets.

Mitochondrial Protein Carboxyl-Terminal Alanine-Threonine Tailing Promotes Human Glioblastoma Growth by Regulating Mitochondrial Function

This study identifies msiCAT-tailing of mitochondrial proteins as a mechanism promoting glioblastoma growth by enhancing mitochondrial function and reducing apoptosis.

Targeting oncogenic K-Ras mutants with a small-molecule degrader through Nedd4-1

This study develops a small-molecule degrader, XMU-MP-9, that promotes ubiquitination and degradation of K-Ras mutants, including K-RasG12V, by enhancing Nedd4-1 interaction with K-Ras.

Heterogeneous efflux pump expression underpins phenotypic resistance to antimicrobial peptides

This study shows that subpopulations of stationary phase bacteria resist antimicrobial peptides through enhanced efflux and other mechanisms, and suggests combining tachyplesin with sertraline to combat resistance.

Adaptive Functions of Structural Variants in Human Brain Development

This study identifies human-specific structural variants in rhesus macaques, showing their impact on human brain development through gene expression changes.

Biologically informed machine learning modeling of immune cells to reveal physiological and pathological aging process

The paper constructs a transcriptomic atlas of immune cells across human lifespan and develops a biological age prediction model using scRNA-seq and bulk RNA-seq data.

DNA damage drives antigen diversification through mosaic VSG formation in Trypanosoma brucei

The paper demonstrates that DNA damage induces VSG recombination in T. brucei, leading to antigenic variation and immune evasion.

Illuminating the Dark Cancer Phosphoproteome Through a Machine-Learned Co-Regulation Map of 26,280 Phosphosites

The paper constructs a co-regulation map of phosphosites using machine learning and phosphoproteomic data, revealing kinase-substrate associations and identifying potential therapeutic targets in cancer.

A rapid and efficient in vivo inoculation method for introducing tree stem canker pathogens onto leaves: Suitable for large-scale assessment of resistance in poplar breeding progeny

This paper introduces an in vivo leaf inoculation method for assessing poplar resistance to V. sordida, showing it is more efficient and suitable for large-scale screening than traditional stem segment inoculation.

A cryopreservation strategy for myoblast storage in paper-based scaffolds for inter-laboratory studies of skeletal muscle health

This paper develops a cryopreservation method for myoblasts in paper-based scaffolds, enabling inter-laboratory studies of skeletal muscle health.

A 10-valent composite mRNA vaccine against both influenza and COVID-19

This paper introduces FLUCOV-10, a 10-valent mRNA vaccine targeting influenza and SARS-CoV-2, showing robust immune responses and complete protection in mice against multiple strains.

Epstein-Barr Virus Orchestrates Spatial Reorganization and Immunomodulation within the Classic Hodgkin Lymphoma Tumor Microenvironment

This study uses spatial multi-omics to compare EBV-positive and EBV-negative cHL, identifying distinct TME features and immunological signatures linked to EBV.

ATG6 interacting with NPR1 increases Arabidopsis thaliana resistance to Pst DC3000/avrRps4 by increasing its nuclear accumulation and stability

This study shows ATG6 interacts with NPR1, enhancing its nuclear accumulation and stability, which boosts Arabidopsis resistance to Pst DC3000/avrRps4.

Stimulation Effects Mapping for Optimizing Coil Placement for Transcranial Magnetic Stimulation

This paper introduces a framework for optimal TMS coil placement without segmentation or meshing, validated across multiple datasets showing consistent results.

Host 5-HT affects Plasmodium transmission in mosquitoes via modulating mosquito mitochondrial homeostasis

This study shows that host 5-HT levels influence Plasmodium transmission in mosquitoes by modulating mitochondrial homeostasis and reactive oxygen species.

Genome-wide CRISPR screen identifies AC9 as a key regulator of ER calcium homeostasis involved in neuronal differentiation.

The paper identifies AC9 as a key regulator of ER calcium homeostasis during neuronal differentiation using CRISPR screening and functional analysis.

BMI1 regulates human erythroid self-renewal through both gene repression and gene activation

This study shows BMI1 promotes erythroid self-renewal through both gene repression and activation, offering a strategy to expand immature erythroid precursors for clinical use.

The transcription factor OsbZIP48 governs rice responses to zinc deficiency

This study identifies OsbZIP48 as a transcription factor critical for rice's response to zinc deficiency, showing it regulates zinc transporter genes through direct promoter binding.

Patient Subtyping Analysis of Baseline Multi-omic Data Reveals Distinct Pre-immune States Predictive of Vaccination Responses

The paper analyzes baseline multi-omic data from influenza vaccine recipients to identify pre-immune states predictive of vaccination responses.