Structural basis of Toxoplasma gondii Perforin-Like Protein 1 membrane interaction and activity during egress
A. J. Guerra, O. Zhang, C. M. E. Bahr, M.-H. Huynh, J. DelProposto, W. C. Brown, Z. Wawrzak, N. M. Koropatkin, V. B. Carruthers
This study identifies the structural basis of TgPLP1 membrane interaction and its role in parasite egress by showing a hydrophobic loop insertion into the membrane is essential for cytolytic activity.
bioRxiv · Sep 2, 2018Microbiology