Global mapping of the energetic and allosteric landscapes of protein binding domains
A. J. Faure, J. Domingo, J. M. Schmiedel, C. Hidalgo-Carcedo, G. Diss, B. Lehner
The paper develops a method using deep mutational scanning to map allosteric landscapes of protein domains, revealing widespread allosteric mutations and their effects on binding affinity.
bioRxiv · Sep 14, 2021 · PreprintBiophysics