Targeting activated macrophages intracellular milieu to augment anti-inflammatory drug potency
V. M. Gouveia, L. Rizzello, B. Vidal, C. Nunes, A. Poma, C. Lopez-Vasquez, E. Scarpa, S. Brander, A. Oliveira, J. E. Fonseca, S. Reis, G. Battaglia
This study demonstrates that pH-responsive polymersomes enhance methotrexate delivery to activated macrophages, improving arthritis treatment while reducing off-target effects.
bioRxiv · Jun 22, 2021Immunology