Author

C. Nunes

Ghent University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Immunology· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:drug response / drug discovery· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Assay:DNA methylation· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

A. Eggermont· 1 shared A. Louwagie· 1 shared A. Oliveira· 1 shared A. Poma· 1 shared Alexander M.M. EggermontiD· 1 shared Anna A. SablinaiD· 1 shared B. De Wilde· 1 shared B. Decaesteker· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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1 shared paperCancer Biology

A. Eggermont

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Author profile →

4 papers

Recent·Most cited

5UTR translational inhibition of neuroblastoma dependency factors using the CR-1-31-B rocaglate

C. Nunes, S.-L. Bekaert, S. Parsa, Iris H. Nelen, F. Martens, Elisa de Stanchina, Ellen Sanders, Elien Hilgert, Sara T’Sas, P. Zhao, Fanny De Vloed, Alexander M.M. Eggermont, Steven Goossens, Anna A. Sablina, Lisa Depestel, , Kaat Durinck

This study evaluates CR-1-31-B's effects on neuroblastoma, showing reduced tumor growth and revealing translational inhibition of key dependencies and synergistic effects with CHK1 inhibition.

bioRxiv · Aug 29, 2024 · PreprintCancer Biology

Targeting activated macrophages intracellular milieu to augment anti-inflammatory drug potency

V. M. Gouveia, L. Rizzello, B. Vidal, C. Nunes, A. Poma, C. Lopez-Vasquez, E. Scarpa, S. Brander, A. Oliveira, J. E. Fonseca, S. Reis, G. Battaglia

This study demonstrates that pH-responsive polymersomes enhance methotrexate delivery to activated macrophages, improving arthritis treatment while reducing off-target effects.

bioRxiv · Jun 22, 2021Immunology

RRM2 is a target for synthetic lethal interactions with replication stress checkpoint addiction in high-risk neuroblastoma

C. Nunes, L. Depestel, L. M. Mus, K. M. Keller, L. Delhaye, A. Louwagie, M. Rishfi, E. M. Dolman, V. Olexiouk, C. Bartenhagen, F. Devloed, E. Sanders, A. Eggermont, J. Van Laere, E. De Smet, , F. Speleman

This study identifies RRM2 as a therapeutic target in high-risk neuroblastoma, showing that combined RRM2 and CHK1 inhibition synergistically reduces tumor growth.

bioRxiv · Nov 25, 2020 · PreprintCancer Biology

SUMOylation of rice DELLA SLR1 modulates transcriptional responses and improves yield under salt stress

N. M. Goncalves, T. Fernandes, C. Nunes, M. T. G. Rosa, C. C. Matiolli, M. A. A. Rodrigues, P. M. Barros, M. M. Oliveira, I. A. Abreu

Artificially increasing SUMOylation of rice DELLA protein SLR1 improves yield under salt stress by modulating GA-related gene expression and blocking interactions with growth regulators.

bioRxiv · Mar 10, 2020Plant Biology