Cell-extrinsic effects in T cell acute lymphoblastic pre-leukemia stem cells mediated by EphA3
A. C. Pliego Zamora, H. Ranasinghe, J. E. Lisle, S. Huang, R. Wadlow, A. M. Scott, A. W. Boyd, C. I. Slape
The paper investigates the role of EphA3 in T cell acute lymphoblastic pre-leukemia stem cells, showing it enables the halt in differentiation of neighboring WT cells, allowing pre-leukemic cells to persist in the thymus.
bioRxiv · Sep 14, 2020 · PreprintCancer Biology