The methyltransferase DOT1L limits activation and the Th1 program in CD4+ T cells during infection and inflammation
S. Scheer, M. Bramhall, J. Runting, B. Russ, A. Zaini, J. Ellemor, G. Rodrigues, J. Ng, C. Zaph
This study shows that DOT1L limits Th1 activation and lineage stability in CD4+ T cells, with implications for immune response regulation.
bioRxiv · Jul 17, 2020 · PreprintImmunology