Protein abundance and folding rather than the redox state of Kelch13 determine the artemisinin susceptibility of Plasmodium falciparum
R. Schumann, E. Bischoff, S. Klaus, S. Möhring, J. Flock, S. Keller, K. Remans, M. Ganter, M. Deponte
The paper investigates whether mutations in Kelch13 affect artemisinin susceptibility through redox changes or protein folding/abundance, finding that impaired folding and reduced abundance are the key factors.
bioRxiv · Jul 2, 2021Biochemistry