M. Ganter

Plasmodium falciparum CRK4 links early mitotic events to the onset of S-phase during schizogony

The paper identifies PfCRK4 as a kinase that links early mitotic events to the onset of S-phase in Plasmodium falciparum schizogony by orchestrating DNA replication and microtubule rearrangement.

An Sfi1-like centrin-interacting centriolar plaque protein affects nuclear microtubule homeostasis.

The paper identifies a novel centrin-interacting centriolar plaque protein in Plasmodium falciparum and shows its role in regulating nuclear microtubule homeostasis.

Malaria parasite centrins assemble by Ca2+-inducible condensation

This study identifies calcium-inducible liquid-liquid phase separation as the mechanism for centrin assembly in Plasmodium and human centrosomes, revealing essential features for reversible condensation and co-condensation.

Repurposing of mitochondria-targeted tamoxifen: Novel anti-cancer drug exhibits potent activity against major protozoan and fungal pathogens.

This paper demonstrates that MitoTam, a mitochondria-targeted tamoxifen analog, effectively kills various pathogens including fungi, Plasmodium falciparum, and trypanosomatid parasites in vitro and in vivo.

Protein abundance and folding rather than the redox state of Kelch13 determine the artemisinin susceptibility of Plasmodium falciparum

The paper investigates whether mutations in Kelch13 affect artemisinin susceptibility through redox changes or protein folding/abundance, finding that impaired folding and reduced abundance are the key factors.

Asynchronous nuclear cycles in multinucleated Plasmodium falciparum enable rapid proliferation

The paper shows that Plasmodium falciparum nuclei replicate DNA asynchronously, leading to heterogeneous progeny numbers and slower replication during overlapping events.

An extended DNA-free intranuclear compartment organizes centrosomal microtubules in Plasmodium falciparum

This study identifies an extended intranuclear compartment in Plasmodium falciparum that nucleates microtubules during schizogony, revealing a novel centrosome structure.

Microscopy-based assay for semi-quantitative detection of SARS-CoV-2 specific antibodies in human sera

The paper develops a semi-quantitative microscopy-based assay to detect SARS-CoV-2 specific antibodies in human sera, providing a sensitive and specific method for serological analysis.