Impaired lysosomal acidification triggers iron deficiency, necrotic cell death and inflammation in vivo
K. F. Yambire, C. Rostosky, T. Watanabe, D. Pacheu-Grau, S. Torres-Odio, A. Sanchez-Guerrero, O. Senderovich, E. G. Meyron-Holtz, I. Milosevic, J. Frahm, A. P. West, N. Raimundo
This study shows that impaired lysosomal acidification causes iron deficiency, mitochondrial dysfunction, necrotic cell death, and inflammation in mice.
bioRxiv · Jul 23, 2019 · PreprintCell Biology