ADAM17 inhibition prevents neutrophilia and lung injury in a mouse model of Covid-19
N. L. Lartey, S. Valle-Reyes, H. Vargas-Robles, K. E. Jimenez-Camacho, I. M. Guerrero-Fonseca, R. Castellanos-Martinez, A. Montoya-Garcia, J. Garcia-Cordero, L. Cedillo-Barron, P. Nava, J. G. Filisola-Villasenor, D. Roa-Velazquez, D. I. Zavala-Vargas, E. Morales-Rios, C. Salinas-Lara, , M. Schnoor
This study shows that ADAM17 inhibition reduces neutrophilia and lung injury in a mouse model of Covid-19 by decreasing inflammation and adhesion molecule expression.
bioRxiv · Apr 10, 2021 · PreprintPathology