Discovery and Development of Novel DNA-PK Inhibitors by Targeting the unique Ku-DNA Interaction
N. S. Gavande, P. S. VanderVere-Carozza, K. S. Pawelczak, T. L. Vernon, L. A. Hanakahi, M. Summerlin, J. R. Dynlacht, A. H. Farmer, C. R. Sears, N. Al Nasrallah, J. Garrett, J. J. Turchi
This study discovers and develops a new class of DNA-PK inhibitors that target the Ku-DNA interaction, enhancing the efficacy of ionizing radiation and gene editing.
bioRxiv · Aug 24, 2020Biochemistry