A. Griffiths

A pan-variant mRNA-LNP T cell vaccine protects HLA transgenic mice from mortality after infection with SARS-CoV-2 Beta

A T cell vaccine based on conserved epitopes protects HLA transgenic mice from SARS-CoV-2 Beta variant mortality without inducing neutralizing antibodies.

Development of a Well-Characterized Cynomolgus Macaque Model of Sudan Virus Disease for Support of Product Development

This study characterizes the disease course in cynomolgus macaques infected with Sudan virus to evaluate its suitability as a model for filovirus countermeasure development under the FDA Animal Rule.

T cell migration requires ion and water influx to regulate actin polymerization

This study shows that chemokine-induced T cell migration requires water entry at the leading edge to facilitate actin polymerization.

Comparative infection and pathogenesis of SARS-CoV-2 Omicron and Delta variants in aged and young Syrian hamsters

This study compares SARS-CoV-2 Delta and Omicron variants' infection dynamics and pathogenesis in aged and young Syrian hamsters, finding Omicron causes less severe disease with no weight loss and reduced tissue damage.

Preclinical Efficacy of IMM-BCP-01, a Highly Active Patient-Derived Anti-SARS-CoV-2 Antibody Cocktail

The paper identifies and characterizes an antibody cocktail, IMM-BCP-01, that neutralizes SARS-CoV-2 variants in vitro and inhibits infection in vivo through Spike Trimer dissociation and effector responses.

A trimeric human angiotensin-converting enzyme 2 as an anti-SARS-CoV-2 agent in vitro

This study creates a trimeric ACE2 variant with high affinity for SARS-CoV-2 spike protein and shows it inhibits viral infection in cell culture.

Immunogenicity of an AAV-based, room-temperature stable, single dose COVID-19 vaccine in mice and non-human primates

This paper evaluates an AAV-based COVID-19 vaccine in mice and non-human primates, showing sustained neutralizing antibodies and memory T-cells, with room-temperature stability and scalable production.

Molecular basis for a germline-biased neutralizing antibody response to SARS-CoV-2

The paper identifies germline-biased neutralizing antibodies against SARS-CoV-2 and shows that affinity gains do not always correlate with neutralization potency.

New water and air pollution sensors added to the Sonic Kayak citizen science system for low cost environmental mapping

The paper introduces two new sensors for turbidity and air particulate pollution to the Sonic Kayak system, enabling low-cost environmental data collection and mapping.

Insights into the secondary structural ensembles of the full SARS-CoV-2 RNA genome in infected cells

This study identifies RNA secondary structures of the full SARS-CoV-2 genome in infected cells, revealing alternative conformations that influence frameshifting rates.

Sonic Kayaks: Environmental monitoring and experimental music by citizens

The paper describes the Sonic Kayak, a citizen science tool that collects environmental data and generates real-time music from underwater sounds and temperatures.