Single cell analysis of blood mononuclear cells stimulated through CD3 and CD28 shows collateral activation of B and NK cells and demise of monocytes
N. T. Lawlor, D. Nehar-Belaid, J. Grassmann, M. Stoeckius, P. Smibert, M. L. Stitzel, V. Pascual, J. Banchereau, A. Williams, D. Ucar
The paper uses single-cell RNA-seq and CITE-seq to analyze PBMC responses to T-cell and monocyte activators, showing differential activation patterns and transcriptional changes in various immune cell types.
bioRxiv · Dec 23, 2020 · PreprintImmunology