Branched-Chain Amino Acid Metabolism is Regulated by ERRα in Primary Human Myotubes and is Further Impaired by Glucose Loading in Type 2 Diabetes
R. J. O. Sjögren, D. Rizo-Roca, A. V. Chibalin, E. Chorell, R. Furrer, S. Katayama, J. Harada, H. K. R. Karlsson, C. Handschin, T. Moritz, A. Krook, E. Näslund, J. R. Zierath
This study shows that type 2 diabetes impairs BCAA catabolism, which is regulated by ERRα via PGC-1 in human myotubes, and glucose loading worsens this impairment.
bioRxiv · Jul 24, 2020Physiology