Author

E. Chorell

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Biochemistry· 1 Cancer Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 5 Research Focus:chromatin & epigenetic regulation· 2 Assay:DNA methylation· 2 Research Focus:drug response / drug discovery· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

M. Doimo· 3 shared S. Wanrooij· 3 shared A. Berner· 2 shared M. Andreasson· 2 shared R. N. Das· 2 shared A. Abrahamsson· 1 shared A. Krook· 1 shared A. U. Eriksson· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersCell Biology

M. Doimo

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

G4-Ligand Conjugated Oligonucleotides Mediate Selective Binding and Stabilization of Individual G4 DNA Structures

A. Berner, R. N. Das, N. Bhuma, J. Golebiewska, A. Abrahamsson, M. Andreasson, N. Chaudhari, M. Doimo, P. P. Bose, K. Chand, R. Stromberg, S. Wanrooij, E. Chorell

The paper develops a method to selectively target and stabilize individual G4 DNA structures using ligand-conjugated oligonucleotides, demonstrating specificity without affecting off-target G4 formations.

bioRxiv · Sep 20, 2023 · PreprintBiochemistry

Enhanced mitochondrial G-quadruplex formation impedes replication fork progression leading to mtDNA loss in human cells

M. Doimo, S. Abrahamsson, V. L'Hote, M. Ndi, R. N. Das, K. Aasumets, A. Berner, S. Goffart, J. L. O. Pohjoismäki, M. Davila, E. Chorell, S. Wanrooij

The paper shows that mitochondrial DNA replication stalling increases G-quadruplex formation, which blocks replication forks and leads to mtDNA loss in human cells.

bioRxiv · Jun 8, 2022Cell Biology

High throughput screen in a co-culture model to uncover therapeutic strategies to potentiate the cancer-inhibiting properties of the tumor-stroma in pancreatic cancer

J. E. Mason, J. Cumming, A. U. Eriksson, C. Binder, M. Dongre, C. Patthey, M. Espona-Fiedler, E. Chorell, D. Ohlund

The paper identifies GNF-5 as a compound that inhibits PDAC tumor cell growth by inducing myCAF phenotype in a co-culture model.

bioRxiv · Mar 11, 2022 · PreprintCancer Biology

Towards customized studies of G-quadruplex DNA structures in live cells

B. Prasad, M. Doimo, M. Andreasson, V. L Hote, E. Chorell, S. Wanrooij

The paper develops a synthetic platform to study G-quadruplex DNA structures in live cells using modified Phen-DC3 compounds with fluorescent and cell-penetrating properties.

bioRxiv · Apr 7, 2021Cell Biology

Branched-Chain Amino Acid Metabolism is Regulated by ERRα in Primary Human Myotubes and is Further Impaired by Glucose Loading in Type 2 Diabetes

R. J. O. Sjögren, D. Rizo-Roca, A. V. Chibalin, E. Chorell, R. Furrer, S. Katayama, J. Harada, H. K. R. Karlsson, C. Handschin, T. Moritz, A. Krook, E. Näslund, J. R. Zierath

This study shows that type 2 diabetes impairs BCAA catabolism, which is regulated by ERRα via PGC-1 in human myotubes, and glucose loading worsens this impairment.

bioRxiv · Jul 24, 2020Physiology