A statistical framework for assessing pharmacological response and biomarkers using uncertainty estimates
D. Wang, J. Hensman, G. Kutkaite, T. S. Toh, GDSC Screening Team, J. R. Dry, J. Saez-Rodriguez, M. Garnett, M. P. Menden, F. Dondelinger
The paper introduces a statistical framework using uncertainty estimates to identify biomarkers from drug screening data, finding 24 known and 6 novel biomarkers in cancer cell lines.
bioRxiv · May 1, 2020 · PreprintCancer Biology