M. P. Menden

MetaIBS performs a large-scale meta-analysis of 16S rRNA amplicon data from IBS patients and healthy controls, identifying consistent microbial taxa differences.

The paper assesses molecular EMT signatures in cancer cell lines to identify drug susceptibilities, showing EMT can predict responses to HSP90 inhibitors and enhance drug sensitivity through TGF-β stimulation.

The paper identifies DNA methylation biomarkers linked to drug sensitivity in cancer cell lines across multiple cancer types and drugs.

This study shows that Nfe2l1 regulates skeletal muscle proteostasis and function, with its loss causing muscle fiber type switching and insulin resistance in high-fat diet conditions.

This study shows that suppressing ferroptosis via antioxidants or vitamin A is necessary for proper neuronal development and laminar organization in cortical organoids.

The paper introduces a statistical framework using uncertainty estimates to identify biomarkers from drug screening data, finding 24 known and 6 novel biomarkers in cancer cell lines.

GDSCTools provides a software package for analyzing pharmacogenomic data to identify genomic markers of drug response in cancer.