D. Wang

Transcriptome-wide identification of 5-methylcytosine by deaminase and reader protein-assisted sequencing

This paper introduces DRAM, a method for transcriptome-wide m5C detection using deaminase and reader proteins, showing high overlap with BS-seq data and supporting low-input RNA.

Molecular Evidence of Internal Carbon-Driven Partial Denitrification Annamox (PdNA) in a mainstream Pilot A-B System Coupled with Side-stream EBPR treating municipal wastewater

This study demonstrates that a pilot-scale A-B-S2EBPR system achieves nitrite accumulation and anammox for nitrogen removal in wastewater treatment by utilizing internal carbon sources.

FLASH radiotherapy using high-energy X-rays: validation of the FLASH effect triggered by a compact single high-energy X-ray source device

This study validates the FLASH effect using a compact high-energy X-ray source in mice, showing protective effects on normal tissues but no significant tumor response differences between FLASH and conventional radiotherapy.

Adipokinetic hormone signaling mediates the enhanced fecundity of Diaphorina citri infected by 'Candidatus Liberibacter asiaticus'

This study identifies adipokinetic hormone signaling as a key mediator of increased fecundity in CLas-infected D. citri, revealing a mutualistic interaction between the bacterium and the insect.

Basal Cambrian soft-bodied segmented bilaterians preserved as microbial pseudomorphs

This study identifies microbial pseudomorphs as the earliest three-dimensional body fossils of segmented bilaterians from the basal Cambrian, revealing a diversified bilaterian world.

Polymerization of Tetraspanin 7 into Helical Transmembrane Skeletons for Tubular Membrane Stabilization

The paper identifies TSPAN7's role in forming helical transmembrane structures that stabilize tubular membrane protrusions by sensing curvature and resisting mechanical stress.

Elucidating the kinetic and thermodynamic insight into regulation of glycolysis by lactate dehydrogenase and its impact on tricarboxylic acid cycle and oxidative phosphorylation in cancer cells

This study investigates how lactate dehydrogenase (LDH) regulates glycolysis, TCA cycle, and oxidative phosphorylation in cancer cells through kinetic and thermodynamic mechanisms, showing that LDH inhibition disrupts metabolic pathways and induces cell death under hypoxia.

Hepatic lipopolysaccharide binding protein partially uncouples inflammation from fibrosis in MAFLD

This study shows that reducing hepatic LBP in mice limits inflammation but not fibrosis in MAFLD, suggesting inflammation may not be a primary driver of fibrosis.

The effects of L-carnitine and fructose in improved Ham's F10 on sperm culture in idiopathic severe asthenospermia within 24h

This study evaluates the effects of L-carnitine and fructose in modified Ham's F10 medium on sperm motility in idiopathic severe asthenospermia patients within 24h, finding improved viability at specific concentrations and temperature.

Entropy Changes in Water Networks Promote Protein Denaturation

This study identifies entropy changes in water networks as a mechanism for ion-induced protein denaturation, revealing an 'inverse hydrophobic effect' that promotes unfolding.

Development of a Time-Resolved Fluorescence Resonance Energy Transfer ultra-high throughput screening assay for targeting SYK and FCER1G interaction

This paper develops a time-resolved fluorescence resonance energy transfer (TR-FRET) assay for screening small molecule inhibitors targeting the SYK and FCER1G interaction, identifying hematoxylin as a hit.

Barcoded SARS-CoV-2 viruses define the impact of time and route of transmission on the transmission bottleneck in a Syrian hamster model.

This study uses barcoded SARS-CoV-2 viruses in Syrian hamsters to show that transmission bottleneck varies by exposure duration and route, with direct contact having the largest bottleneck.

Pulmonary Fibrosis Ferret Model Demonstrates Sustained Fibrosis, Restrictive Physiology, and Aberrant Repair

This study shows that bleomycin-exposed ferrets develop sustained pulmonary fibrosis, restrictive lung physiology, and airway remodeling similar to human IPF.

Serosurveillance and first detection of Bourbon virus RNA in a wildlife host

The paper detects BRBV RNA in a coyote and identifies seropositive wildlife species in St. Louis, linking tick density and host composition to BRBV exposure.

Adipocyte microRNA-802 promotes adipose tissue inflammation and insulin resistance by modulating macrophages in obesity

This study shows that miR-802 in adipose tissue promotes inflammation and insulin resistance by modulating macrophage recruitment and polarization in obesity.

Methyltransferase DNMT3B promotes colorectal cancer cell proliferation by inhibiting PLCG2

This study identifies DNMT3B as a promoter of colorectal cancer cell proliferation by inhibiting PLCG2 transcription through promoter methylation.

Targeting protein tyrosine phosphatase non-receptor type 2 with a novel inhibitor for AML therapy

This study identifies PTPN2 as a therapeutic target in AML, discovers a selective inhibitor K73, and demonstrates its efficacy in reducing AML burden in vitro and in vivo.

Genome Assembly of Docynia delavayi Provides New Insights into α-Farnesene Biosynthesis

This study reports the first high-quality genome of Docynia delavayi and identifies key genes and transcription factors involved in α-farnesene biosynthesis, a major aroma compound in its fruit.

Propiconazole and Tianfengsu Regulated the Growth, Flavor, and Nutrition of Brassica rapa by Brassinosteroid Pathway

This study examines how Propiconazole and Tianfengsu affect Brassica rapa growth, flavor, and nutrition through the brassinosteroid pathway, showing synergistic benefits when used together.

Multiple Omics Find New Cecal Microbial Features Associated with Feed Efficiency in Ducks

The paper identifies microbial and metabolic differences associated with feed efficiency in ducks using metagenomics, transcriptomics, and metabolomics.

Calculating Protein-Ligand Residence Times Through State Predictive Information Bottleneck based Enhanced Sampling

This paper introduces a method to calculate protein-ligand residence times across wide timescales using deep learning and enhanced sampling.

Medium Composition Affects Microbial Corrosion Rates

The paper shows that medium composition affects microbial corrosion rates, with D. vulgaris outperforming D. ferrophilus in marine conditions despite initial assumptions about their mechanisms.

Chloride Homeostasis Regulates cGAS-STING Signaling

This study shows chloride homeostasis regulates cGAS-STING signaling by affecting 23-cGAMP production, STING polymerization, and cytokine production in immune cells.

Whole-genome resequencing revealed the Origin and Domestication of Chinese Domestic Rabbits

This study uses whole-genome resequencing to trace the origin and domestication of Chinese domestic rabbits, identifying genetic adaptations and multiple potential origins.

Self-quenched fluorophore-DNA labels for super-resolution fluorescence microscopy

The paper introduces self-quenched fluorophore-DNA labels to reduce background signal in super-resolution microscopy, improving imaging performance in STED and SMLM.

Elucidating Microbial Iron Corrosion Mechanisms with a Hydrogenase-Deficient Strain of Desulfovibrio vulgaris

This study investigates Fe0 corrosion by a hydrogenase-deficient mutant of Desulfovibrio vulgaris, showing H2 oxidation indirectly promotes corrosion via sulfide generation, not direct electron transfer.

Targeting Diffuse Midline Glioma with a novel anti-CD99 Antibody

This paper identifies CD99 as a therapeutic target in K27M+DMGs, showing that a novel anti-CD99 antibody reduces tumor growth and enhances radiation efficacy in preclinical models.

Engineered Migrasomes: Harnessing Core Migrasome Machinery and Hypotonic Shock to Develop a Robust and Thermally Stable Vaccine Platform

This study engineers migrasome-like vesicles (eMigrasomes) using hypotonic shock to create a stable, thermally robust vaccine platform that elicits strong immune responses.

Transcriptional Regulation of Protein Synthesis by Mediator Kinase in MYC-driven Medulloblastoma

This study identifies CDK8 as a critical dependence in MYC-driven medulloblastoma, showing its role in regulating transcription and translation through mechanisms involving ribosome biogenesis and 4EBP1 phosphorylation.

Testing a Method for Quantifying Microplastic Content in Mytilus californianus

The paper tests a method to isolate and quantify microplastics in Mytilus californianus using digestion, sonication, and fluorescent microscopy.