J. J. Bouchard

Reduction of oligomer size modulates the competition between cluster formation and phase separation of the tumor suppressor SPOP

This study shows that reducing SPOP oligomer size shifts its function from cluster formation to phase separation, enhancing ubiquitination activity and providing insights into separation-of-function mutations.

Protein network structure enables switching between liquid and gel states

The paper uses analytic theory to show how protein interactions determine phase separation behavior, revealing that gel formation is driven by entropy rather than binding energy.