J. Lee

Molecular Evidence of Internal Carbon-Driven Partial Denitrification Annamox (PdNA) in a mainstream Pilot A-B System Coupled with Side-stream EBPR treating municipal wastewater

This study demonstrates that a pilot-scale A-B-S2EBPR system achieves nitrite accumulation and anammox for nitrogen removal in wastewater treatment by utilizing internal carbon sources.

Protein Kinases MpkA and SepH Transduce Crosstalk Between CWI and SIN Pathways to Activate Protective Hyphal Septation Under Echinocandin Cell Wall Stress

This study identifies crosstalk between the CWI and SIN pathways in fungi, showing that it enables hyperseptation under echinocandin stress, which contributes to resistance.

Computationally designed mRNA-launched protein nanoparticle vaccines

This paper develops an mRNA-launched nanoparticle vaccine that combines protein nanoparticle and mRNA vaccine advantages, showing enhanced antibody and T cell responses in mice.

Highly ordered clustering of TNFα and BAFF ligand-receptor-adaptor complexes bound to lipid membranes

The paper reports cryo-EM structures of TNF and BAFF ligand-receptor-adaptor complexes clustered on lipid membranes, showing that ordered clustering is essential for receptor activation.

Robust Binding Capability and Occasional Gene Loss of Telomere-Binding Proteins Underlying Telomere Evolution in Nematoda

The paper investigates how telomere repeats evolved in nematodes despite the specificity of telomere-binding proteins, finding that protein conservation and binding affinity correlate with the emergence of novel telomeric motifs.

Transient TELC and transmembrane potential in a laser flashed bacteriorhodopsin purple membrane open flat sheet

The paper analyzes transient TELC and transmembrane potential in laser flashed bacteriorhodopsin purple membranes, finding a peak transient transmembrane potential of 50 mV.

Condenzymes: Biomolecular condensates with inherent catalytic activities

The paper discovers that intrinsically disordered proteins form condensates with catalytic activity through sequence-dependent electrochemical microenvironments, enabling hydrolysis reactions and gene circuit activation in cells.

Evolutionary diversity of cell-type-specific expression and stress response in Brassicaceae roots

This study profiles root cells from five Brassicaceae species under stress treatments, revealing cell-type-specific gene expression divergence and stress response variation across species.

Chronic Social Defeat Stress Gives Rise to Social Avoidance Through Fear Learning

This study shows that chronic social defeat stress leads to social avoidance through fear learning in mice, with conditioned responses to social targets.

Lymphoid origin of a lineage of intrinsically activated plasmacytoid dendritic cell in mice and humans

The paper identifies a novel plasmacytoid dendritic cell lineage in mice and humans derived from common lymphoid progenitors, characterized by unique gene expression and functional properties.

Molecular tension authenticates apoptotic cells being phagocytosed

The paper identifies molecular tension between phosphatidylserine and its receptors as a signal determining phagocytosis of apoptotic cells.

Determination of the absolute concentration of Rayleigh particles via scattering microscopy

This paper introduces iCAUNT, a method to measure the absolute concentration of nanoparticles smaller than one-tenth of the imaging light wavelength using scattering microscopy.

Mechanical Rejuvenation of Mesenchymal Stem Cells from Aged Patients

This study shows that mechanical conditioning improves the regenerative potential of aged mesenchymal stem cells by reducing senescence and altering their genetic landscape.

Phylogeny and species delimitation of ciliates in the genus Spirostomum (Class, Heterotrichea) using single-cell transcriptomes

This study uses single-cell transcriptomes to reveal cryptic species and phylogenetic relationships in Spirostomum ciliates, identifying at least nine cryptic species.

Mapping and Engineering Antibody-Antigen Interaction Landscapes for Systematic Affinity Enhancement

The paper introduces a method to map antibody-antigen interactions using SPID platform to enhance affinity prediction and optimize antibody design.

The second messenger signaling molecule cyclic di-AMP drives developmental cycle progression in Chlamydia trachomatis

This study identifies c-di-AMP as a key factor triggering secondary differentiation in Chlamydia trachomatis by linking its levels to changes in EB production and gene transcription.

Realigning representational drift in mouse visual cortex by flexible brain-machine interfaces

This study uses flexible electrodes to track and model representational drift in mouse visual cortex, enabling a stable decoder for brain-machine interfaces.

The role of mu-opioid receptors in pancreatic islet alpha cells

This study investigates the role of mu-opioid receptors in pancreatic islet alpha cells, showing they regulate glucagon secretion and are linked to metabolic disease.

Single-cell and spatial atlas of steatotic liver-related hepatocellular carcinoma

This study characterizes the tumor microenvironment of steatotic liver-related hepatocellular carcinoma using single-cell and spatial transcriptomic analyses, identifying immunosuppressive features and Treg-CAF interactions linked to immunotherapy resistance.

Domain consolidation in Bacterial 50S assembly revealed by Anti-Sense Oligonucleotide Probing

The paper uses anti-sense oligonucleotides to disrupt RNA interactions in bacterial ribosome assembly, revealing intermediate structures and domain consolidation during RNP formation.

An imbalance between proliferation and differentiation underlies the development of microRNA-defective pineoblastoma

This study shows that loss of microRNA processing genes leads to tumor development by disrupting proliferation and differentiation balance, and suggests targeting downstream drivers could be therapeutic.

A FOXA1/SPDEF Co-regulatory Axis Drives ERBB2 and Suppresses TEAD/YAP-Driven EMT to Maintain Luminal Identity in HER2+ Breast Cancer

This study identifies a FOXA1/SPDEF co-regulatory axis that drives ERBB2 expression and suppresses EMT in HER2+ breast cancer, maintaining luminal identity and serving as a therapeutic target.

Mosaic display of stable hemagglutinin monomers induces broad immune responses

This study develops a nanoparticle vaccine displaying conserved influenza HA epitopes, inducing broad neutralizing antibodies against multiple viral subtypes.

Lgr5+ intestinal stem cells are required for organoid survival after genotoxic injury

This study shows that Lgr5+ intestinal stem cells are necessary for organoid survival after genotoxic injury, despite fISC gene activation occurring at both low and high doses of doxorubicin.

Determining the Youngs Modulus of the Bacterial Cell Envelope

The paper measures the Young's modulus of bacterial cell envelopes in E. coli, V. cholerae, and S. aureus using a microfluidic system and inverse finite element analysis, finding values ranging from 0.12 to 2.06 MPa.

Responses to membrane potential-modulating ionic solutions measured by magnetic resonance imaging of cultured cells and in vivo rat cortex

This study uses MRI to measure responses of cultured cells and in vivo rat cortex to ionic solutions that modulate membrane potential, finding changes in T2 relaxation time and bound-to-free water proton ratio.

miR-644a is a tumor cell-intrinsic mediator of sex bias in glioblastoma

This study identifies miR-644a as a tumor cell-intrinsic mediator of sex bias in glioblastoma, showing it is more highly expressed in females and its target genes are linked to poorer survival.

Direct inhibitors of InhA with efficacy similar or superior to isoniazid in novel drug regimens for tuberculosis

This study evaluates direct inhibitors of InhA (DIIs) for tuberculosis treatment, showing their efficacy comparable to isoniazid and their potential in new drug regimens.

Human Foot Force Informs Balance Control Strategies when Standing on a Narrow Beam

This study uses intersection point analysis of ground reaction forces to show that humans minimize joint effort by adjusting ankle and hip torques during balance on a narrow beam.

Genetic regulation and targeted reversal of lysosomal dysfunction and inflammatory sterol metabolism in pulmonary arterial hypertension

The paper identifies NCOA7's role in lysosomal function and inflammatory sterol metabolism in PAH, showing its deficiency exacerbates disease through oxysterol/bile acid generation.