BiochemistrybioRxiv
Self-oligomerization regulates stability of Survival Motor Neuron (SMN) protein isoforms by sequestering an SCFSlmb degron
K. M. Gray, K. A. Kaifer, D. Baillat…·A. G. Matera
The paper identifies SCFSlmb as a regulator of SMN protein stability through a degron, showing that self-oligomerization stabilizes SMN isoforms and mitigates SMA severity.
DOI 10.1091/mbc.e17-11-0627