A. I. Lamond

This paper develops a workflow to identify proline hydroxylation sites using HILIC and LC-MS, finding 4,993 and 3,247 sites in HEK293 and RCC4 cells, respectively.

The paper develops a drug screening platform using hiPSC lines from different donors to predict variable drug responses and mechanisms, showing potential for improving drug safety across diverse genetic backgrounds.

This study uses SEC-MS to analyze HSP90 inhibitor effects on protein complexes, identifying both known and novel components of the HSP90-dependent proteome.

The paper identifies reader proteins for 5-methylcytosine and its derivatives in C. elegans RNA using modified RNA baits and mass spectrometry.

This study shows Nrf2 regulates macrophage metabolism, redox balance, and inflammatory responses, with 4-OI modulating these effects through Nrf2.

The paper uses proteomic analysis to show that the gut environment, not developmental origin, shapes the functional properties of intestinal intraepithelial T lymphocytes.

This study shows Cyclin A can trigger mitosis through Greatwall or Cyclin B by regulating Cdk1 activity and phosphorylation of mitotic substrates.

The paper investigates how PIWI and DEPS-1 interact to support piRNA function and condensate structure in C. elegans.

This study shows antigen receptor engagement controls methionine cycle flux and methyl donor availability for RNA and histone methylation in T cells.

This paper identifies PIP30/FAM192A as a novel cofactor of PA28gamma, showing it binds to PA28gamma and modulates its interactions with the 20S proteasome and coilin.

The paper uses PRIMMUS to analyze proteomic changes during cell cycle progression, identifying phosphorylation sites and their roles in mitotic progression.

This study identifies hinokiflavone as a splicing inhibitor that modulates alternative splicing by inhibiting SUMO protease SENP1 and altering SUMOylation of splicing factors.

The paper identifies SCFSlmb as a regulator of SMN protein stability through a degron, showing that self-oligomerization stabilizes SMN isoforms and mitigates SMA severity.