Author

J. K. Lodge

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Organism:C. elegans· 1 Research Focus:drug response / drug discovery· 1 Organism:fungi (other)· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

W. C. Lam· 3 shared C. R. Hole· 2 shared C. Specht· 2 shared R. Upadhya· 2 shared A. E. Ragsdale· 1 shared B. T. Maybruck· 1 shared M. J. Donlin· 1 shared M. X. G. Ilagan· 1 shared

Activity by Year

2019-2020 · peak 2/yr

Co-Author Collaboration Network

9 top collaborators · 24 mutual co-author links

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3 shared papersMicrobiology

W. C. Lam

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Cryptococcus neoformans Chitin Synthase 3 (Chs3) Plays a Critical Role in Dampening Host Inflammatory Responses

C. R. Hole, W. C. Lam, R. Upadhya, J. K. Lodge

This study shows that Chs3 in Cryptococcus neoformans is critical for forming chitosan, which dampens host inflammatory responses, as chs3-deficient strains induce severe hyperinflammatory death in mice.

mBio · Feb 25, 2020Peer-reviewedImmunology

Chitosan biosynthesis and virulence in the human fungal pathogen Cryptococcus gattii

W. C. Lam, R. Upadhya, C. Specht, A. E. Ragsdale, C. R. Hole, S. M. Levitz, J. K. Lodge

This study shows that C. gattii R265 has higher chitosan in its cell wall and that CDA3 is critical for its virulence, with CDA deletions making it avirulent.

mSphere · Oct 30, 2019Peer-reviewedMicrobiology

The aminoalkylindole, BML-190, negatively regulates chitosan synthesis via the cAMP/PKA1 pathway in Cryptococcus neoformans

B. T. Maybruck, W. C. Lam, C. Specht, M. X. G. Ilagan, M. J. Donlin, J. K. Lodge

This paper identifies BML-190 as a compound that reduces chitosan synthesis in Cryptococcus neoformans via the cAMP/PKA1 pathway, suggesting a potential new therapeutic target.

bioRxiv · Aug 29, 2019Microbiology