Author

C. Specht

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 4 Organism:mouse· 3 Organism:C. elegans· 1 Research Focus:drug response / drug discovery· 1 Organism:fungi (other)· 1

Frequent Co-Authors

S. M. Levitz· 4 shared C. K. Lee· 3 shared C. L. Gomez· 3 shared W. C. Lam· 3 shared C. R. Hole· 2 shared J. K. Lodge· 2 shared L. V. N. Oliveira· 2 shared M. M. Hester· 2 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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4 shared papersImmunology

S. M. Levitz

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Author profile →

5 papers

Recent·Most cited

Immunological correlates of protection mediated by a whole organism Cryptococcus neoformans vaccine deficient in chitosan

C. Specht, R. Wang, L. V. N. Oliveira, M. M. Hester, C. L. Gomez, Z. Mou, D. Carlson, C. K. Lee, C. R. Hole, W. C. Lam, R. Upadhya, J. Lodge, S. M. Levitz

This paper identifies CD4+ T cells and their cytokines IFNγ, TNF, and IL-23 as critical for vaccine-mediated protection against Cryptococcus neoformans, with protection retained after vaccination even with CD4+ T cell depletion.

bioRxiv · Jun 12, 2024 · PreprintImmunology

Dysregulated Pulmonary Inflammatory Responses Exacerbate the Outcome of Secondary Aspergillosis Following Influenza

C. K. Lee, L. V. N. Oliveira, A. Akalin, C. Specht, D. Lourenco, C. L. Gomez, Z. G. Ramirez-Ortiz, J. P. Wang, S. M. Levitz

This study shows that superinfected mice with influenza and Aspergillus fumigatus have higher mortality during early influenza stages due to dysregulated inflammation, not increased fungal growth.

bioRxiv · Jun 27, 2023Immunology

Protection of mice against experimental cryptococcosis by synthesized peptides delivered in glucan particles

C. Specht, E. J. Homan, C. K. Lee, Z. Mou, C. L. Gomez, M. M. Hester, A. Abraham, F. Rus, G. Ostroff, S. M. Levitz

The paper shows that glucan particle-based vaccines containing specific peptides from C. neoformans proteins can protect mice against cryptococcosis, with varying efficacy depending on the peptide and mouse strain.

bioRxiv · Nov 12, 2021Immunology

Chitosan biosynthesis and virulence in the human fungal pathogen Cryptococcus gattii

W. C. Lam, R. Upadhya, C. Specht, A. E. Ragsdale, C. R. Hole, S. M. Levitz, J. K. Lodge

This study shows that C. gattii R265 has higher chitosan in its cell wall and that CDA3 is critical for its virulence, with CDA deletions making it avirulent.

mSphere · Oct 30, 2019Peer-reviewedMicrobiology

The aminoalkylindole, BML-190, negatively regulates chitosan synthesis via the cAMP/PKA1 pathway in Cryptococcus neoformans

B. T. Maybruck, W. C. Lam, C. Specht, M. X. G. Ilagan, M. J. Donlin, J. K. Lodge

This paper identifies BML-190 as a compound that reduces chitosan synthesis in Cryptococcus neoformans via the cAMP/PKA1 pathway, suggesting a potential new therapeutic target.

bioRxiv · Aug 29, 2019Microbiology