Signaling Diversity Enabled by Rap1-Regulated Plasma Membrane ERK with Distinct Temporal Dynamics
J. Keyes, A. Ganesan, O. Molinar-Inglis, A. Hamidzadeh, M. Ling, J. Trejo, A. Levchenko, J. Zhang
The paper shows EGF induces sustained plasma membrane ERK activity regulated by Rap1, distinct from transient cytoplasmic and nuclear ERK activity, highlighting spatial-temporal regulation in signaling specificity.
bioRxiv · Sep 25, 2019Cell Biology