J. Zhang

The diversity of disease-associated natural human antibody specificities declines dramatically in Alzheimers disease.

The paper investigates antibody specificity diversity in Alzheimer's disease and finds a 26-fold decline in diversity compared to cognitively normal individuals, with specific epitopes linked to amyloid proteins.

Quantal PCR: A Calibrator-Free Method for Determining the Unit for Nucleic Acid Quantification

This paper introduces quPCR, a calibrator-free method for absolute nucleic acid quantification by defining an intrinsic quantal unit based on replication system properties.

Early multi-omic signatures and machine learning models predict cardiomyocyte differentiation efficiency and enable robust hPSC differentiation to cardiomyocytes

PanCanSurvPlot: A Large-scale Pan-cancer Survival Analysis Web Application

PanCanSurvPlot provides a web tool for large-scale pan-cancer survival analysis with 215 datasets, 45,000 samples, and customizable survival plots.

Loss function of tumor suppressor FRMD8 confers resistance to tamoxifen therapy via a dual mechanism

This study identifies FRMD8 as a regulator of ER levels in ER-positive breast cancer, showing it confers tamoxifen resistance through dual mechanisms involving transcriptional and post-translational regulation of ER.

Dynamic Regulation of Innate Lymphoid Cell Development During Ontogeny

This study investigates the developmental changes in innate lymphoid cell (ILC) subsets using scRNA-seq and differentiation assays, revealing distinct regulatory programs in fetal and adult stages.

A MSTNDel273C mutation with FGF5 knockout sheep by CRISPR/Cas9 promotes skeletal muscle myofiber hyperplasia

This paper describes the creation of MSTNDel273C mutation with FGF5 knockout sheep using CRISPR/Cas9, resulting in skeletal muscle myofiber hyperplasia and a 'double-muscle' phenotype.

Deletion of wheat alpha-gliadins from chromosome 6D improves gluten strength and reduces immunodominant celiac disease epitopes

This study deletes wheat alpha-gliadins from chromosome 6D to improve gluten strength and reduce celiac disease epitopes.

Dynamin 1-mediated endocytic recycling of glycosylated N-cadherin sustains the plastic mesenchymal state to promote ovarian cancer metastasis

This study identifies DNM1 as a master regulator of EMT in ovarian cancer, showing it sustains the mesenchymal state through N-cadherin endocytic recycling and promotes metastasis.

Comprehensive Biosynthetic Analysis of Human Microbiome Reveals Diverse Protective Ribosomal Peptides

This study identifies diverse ribosomally synthesized peptides in the human microbiome and shows some inhibit pathogens and reduce inflammation.

Systematically investigating and identifying bacteriocins in the human gut microbiome

The paper introduces IIBacFinder to identify unmodified class II bacteriocins in the human gut microbiome, showing their widespread distribution and biosynthetic potential.

Lectin Microarray Analysis of Salivary Gland Glycoproteins from the Arboviral Vector Aedes aegypti and the Malaria Vector Anopheles stephensi

The paper uses lectin microarrays to analyze glycoproteins in salivary glands of Aedes aegypti and Anopheles stephensi, finding similar glycan profiles with specific oligomannose and O-glycan presence.

Human microbiome-derived peptide affects the development of experimental autoimmune encephalomyelitis via molecular mimicry

This study identifies a gut microbiome-derived peptide that mimics a myelin antigen and induces experimental autoimmune encephalomyelitis in mice.

Mechanical evolution of metastatic cancer cells in three-dimensional microenvironment

This study uses optical Brillouin microscopy to analyze mechanical features of cancer spheroids over time, showing improved classification accuracy using these features.

Sulfur Amino Acid Restriction Enhances Exercise Capacity in Mice by Boosting Fat Oxidation

SAAR improves exercise capacity in mice by enhancing fat oxidation and substrate availability through VEGF signaling and CD36-dependent fatty acid transport.

Compromising tyrosine hydroxylase function establishes a delusion-like temporal profile of reinforcement by dopamine neurons in Drosophila

This study shows that impairing tyrosine hydroxylase in Drosophila alters dopamine neuron reinforcement timing, mimicking delusional causality attribution in different conditioning paradigms.

Leveraging Crosslinker Diffusion to Template Stiffness Gradients in Alginate Hydrogels

This paper develops a method to create stiffness gradients in alginate hydrogels using stencils, enabling the study of mechanosensitive cell behaviors like cancer cell invasion.

Molecular Architecture of Monkeypox Mature Virus

This study uses cryo-ET and STA to reveal the architecture of mature MPXV particles and identifies irregular virions with distorted core walls.

Chemically induced cell plasticity enables the generation of high-fidelity embryo model

This paper develops a chemical-only method to generate high-fidelity embryo models by inducing cell plasticity in stem cells, resulting in embryo-like structures that recapitulate early developmental stages.

Hyperporous encapsulation of microbes for whole cell biocatalysis and biomanufacturing

This paper develops a hyper-porous hydrogel encapsulation method for microbial cells, demonstrating improved biocatalytic efficiency in co-culture fermentation.

Cell fate plasticity of xylem-pole-pericycle in Arabidopsis roots

This study investigates the cell fate plasticity of xylem-pole-pericycle cells in Arabidopsis roots, showing how auxin and cytokinins regulate their ability to form lateral roots or contribute to cambium.

Polyamine Depletion by D, L-alpha-difluoromethylornithine Inhibits Ewing Sarcoma Metastasis by Inducing Ferroptosis

This study shows DFMO inhibits Ewing sarcoma metastasis by inducing ferroptosis through polyamine depletion.

Calorie Restriction Induces Degeneration of Neurons with Mitochondrial DNA Depletion by Altering ER-Mitochondria Calcium Transfer

This study shows that calorie restriction exacerbates neuronal degeneration in mtDNA-depleted neurons by increasing ER-mitochondria calcium transfer, suggesting CR may not be beneficial for mitochondrial epilepsy.

Embracing Uncertainty Reshapes the ETHYLENE INSENSITIVE2-Activated Ethylene Signaling Framework

The paper challenges the current model of ethylene signaling by showing EIN2 activation can occur independently of CTR1, ETP1/ETP2, and MHL1/MHL2, and reveals new interactions and regulatory mechanisms.

Occurrence, risk assessment of antibiotics and antimicrobial resistance in Escherichia coli in typical rivers of Sichuan

This study assesses antibiotic and antimicrobial resistance in Escherichia coli from Sichuan rivers, finding high contamination and resistance rates, with specific antibiotics linked to ecological risk.

Identification of a gene expression signature of vascular invasion and recurrence in stage I lung adenocarcinoma via bulk and spatial transcriptomics

Differences in systemic immune parameters in individuals with lung cancer according to race

The paper compares systemic immune parameters between Black and White lung cancer patients, finding significant differences in cytokine levels and immune cell populations.

Diminished Immune Cell Adhesion in Hypoimmune ICAM-1 Knockout Pluripotent Stem Cells

This paper identifies ICAM-1 as a novel hypoimmune target in human pluripotent stem cells, showing that its knock-out reduces immune cell adhesion and enhances graft survival.

P-cadherin mechanoactivates tumor- mesothelium metabolic coupling to promote ovarian cancer metastasis

This study shows that P-cadherin-mediated mechanical forces on mesothelial cells enhance lipid production in ovarian cancer cells, promoting metastasis through lactate-driven lipogenesis.

Structures of PSI-FCPI from Thalassiosira pseudonana in high light provide convergent evolution and light-adaptive strategies in diatom FCPIs

The paper reports cryo-EM structures of PSI-FCPI complexes from Thalassiosira pseudonana under high light, revealing light-adaptive strategies and convergent evolution in diatom FCPIs.