Author

A. Levchenko

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 2 Evolutionary Biology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 5 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Research Focus:chromatin & epigenetic regulation· 3 Approach:experimental assay· 3 Approach:statistical model· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2

Frequent Co-Authors

A. Dighe· 2 shared A. Hamidzadeh· 2 shared G. P. Wagner· 2 shared J. Maziarz· 2 shared A. Ganesan· 1 shared A. IbrahimHashim· 1 shared A. Singhal· 1 shared C. Baez· 1 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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2 shared papersEvolutionary Biology

A. Dighe

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Solid tumor growth depends on an intricate equilibrium of malignant cell states

S. R. Torborg, O. Grbovic-Huezo, A. Singhal, M. Holm, K. Wu, X. Han, Y.-J. Ho, C. Haglund, M. J. Mitchell, S. W. Lowe, L. E. Dow, K. L. Pitter, F. J. Sanchez-Rivera, A. Levchenko, T. Tammela

This study identifies a stereotypic organization of pancreatic ductal adenocarcinoma cells based on WNT signaling and Notch ligand interactions, showing that disrupting this equilibrium suppresses tumor growth and metastasis.

bioRxiv · Dec 30, 2023 · PreprintCancer Biology

Experimental and Phylogenetic Evidence for Correlated Gene Expression Evolution between Dermal and Endometrial Fibroblasts: implications for the evolution of cancer malignancy

A. Dighe, J. Maziarz, A. IbrahimHashim, R. Gatenby, Kshitiz, A. Levchenko, G. P. Wagner

The paper investigates correlated gene expression evolution between dermal and endometrial fibroblasts across species and in an experimental model, finding significant correlations that support evolutionary links to cancer malignancy.

bioRxiv · Jul 8, 2023 · PreprintEvolutionary Biology

CTLA-4 tail fusion enhances CAR-T anti-tumor immunity

X. Zhou, H. Cao, S.-Y. Fang, R. D. Chow, K. Tang, M. Majety, M. Bai, M. B. Dong, P. A. Renauer, X. Shang, K. Suzuki, A. Levchenko, S. Chen

This study enhances CAR-T cell efficacy by fusing CTLA-4 cytoplasmic tails to CARs, improving anti-tumor responses in a leukemia model.

bioRxiv · Mar 14, 2023 · PreprintImmunology

Translational control as a novel regulator of gradient sensing and chemotropism in yeast

R. Gelin-Licht, P. J. Conlon, R. Singh, G. Haimovich, C. Baez, L. Gal, M. Schuldiner, A. Levchenko, J. E. Gerst

This study identifies translational control as a regulator of chemotropism in yeast by discovering genes involved in gradient sensing and mating.

bioRxiv · Dec 13, 2020 · PreprintCell Biology

Human vulnerability to cancer malignancy is enhanced by evolution of higher mesenchymal CD44 expression compared to other mammals

X. Ma, A. Dighe, J. Maziarz, E. Neumann, E. Erkenbrack, Y.-Y. Hei, Y. Liu, Y. Suhail, K. Kshitiz, I. Pak, A. Levchenko, G. Wagner

This study shows that increased CD44 expression in human skin and endometrial stromal fibroblasts, compared to other mammals, correlates with higher cancer vulnerability.

bioRxiv · Aug 3, 2020 · PreprintEvolutionary Biology

Signaling Diversity Enabled by Rap1-Regulated Plasma Membrane ERK with Distinct Temporal Dynamics

J. Keyes, A. Ganesan, O. Molinar-Inglis, A. Hamidzadeh, M. Ling, J. Trejo, A. Levchenko, J. Zhang

The paper shows EGF induces sustained plasma membrane ERK activity regulated by Rap1, distinct from transient cytoplasmic and nuclear ERK activity, highlighting spatial-temporal regulation in signaling specificity.

bioRxiv · Sep 25, 2019Cell Biology

The Evolution of Placental Invasion and Cancer Metastasis are Causally Linked

K. Gupta, J. Afzal, J. D. Maziarz, A. Hamidzadeh, C. Liang, E. M. Erkenbrack, H. Nam, J.-D. Haeger, C. Pfarrer, T. Hoang, T. Ott, T. Spencer, M. Pavlicev, D. Antczak, A. Levchenko, G. P. Wagner

The paper links placental invasion and cancer metastasis by showing that human stromal cells are more permissive to invasion than bovine cells, supporting the Evolved Levels of Invasibility hypothesis.

bioRxiv · Jan 23, 2019Cancer Biology