Interference of Neuronal TrkB Signaling by the Cannabis-Derived Flavonoids Cannflavins A and B
J. Holborn, A. Walczyk Mooradally, C. Perrin, B. Alural, C. Aitchison, A. Borenstein, J. Khokhar, T. Akhtar, J. Lalonde
This study shows that cannflavins A and B inhibit TrkB signaling in neurons by preventing Arc protein accumulation and downstream signaling, without agonist activity on GPCRs.
bioRxiv · Feb 3, 2022Pharmacology & Toxicology