Pharmacology & ToxicologybioRxiv
Interference of Neuronal TrkB Signaling by the Cannabis-Derived Flavonoids Cannflavins A and B
J. Holborn, A. Walczyk Mooradally, C. Perrin…·J. Lalonde
This study shows that cannflavins A and B inhibit TrkB signaling in neurons by preventing Arc protein accumulation and downstream signaling, without agonist activity on GPCRs.
DOI 10.1016/j.phyplu.2023.100410