Structural and mechanistic insights into activation of the human RNA ligase RTCB by Archease
J. L. Gerber, S. I. M. Guzman, L. Worf, P. Hubbe, J. Kopp, J. Peschek
The paper reports structural and biochemical analysis of the human RTCB-Archease complex during RNA ligation, revealing the mechanism of GTP-dependent activation and substrate regulation.
bioRxiv · Mar 30, 2023Biochemistry