Author

J. L. Sottnik

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

M. J. Sikora· 3 shared M. T. Shackleford· 2 shared S. Mehrotra· 2 shared A. E. Goodspeed· 1 shared A. L. Richer· 1 shared B. G. Bitler· 1 shared B. R. Corr· 1 shared C. E. Rowland· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersCancer Biology

M. J. Sikora

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3 papers

Recent·Most cited

Co-regulator activity of Mediator of DNA Damage Checkpoint 1 (MDC1) is associated with DNA repair dysfunction and PARP inhibitor sensitivity in lobular carcinoma of the breast

J. L. Sottnik, M. T. Shackleford, C. S. Nesiba, A. L. Richer, Z. Fleischmann, J. M. Swartz, C. E. Rowland, M. Musick, R. Fu, L. R. Myler, P. L. Opresko, S. Mehrotra, E. S. Sokol, J. R. Hesselberth, J. R. Diamond, M. J. Sikora

This study identifies MDC1's role in ER co-regulation and DNA repair dysfunction in ILC, linking it to PARP inhibitor sensitivity.

bioRxiv · Oct 29, 2023Cancer Biology

WNT4 regulates cellular metabolism via intracellular activity at the mitochondria in breast and gynecologic cancers

J. L. Sottnik, M. T. Shackleford, F. R. Villagomez, S. Bahnassy, S. Oesterreich, J. Hu, Z. Madak-Erdogan, R. B. Riggins, B. R. Corr, L. S. Cook, L. S. Trevino, B. G. Bitler, M. J. Sikora

This study identifies WNT4's role in regulating cancer metabolism through mitochondrial intracellular signaling in breast and gynecologic cancers, linking genetic variants to metabolic remodeling.

bioRxiv · Jul 15, 2022Cancer Biology

Mediator of DNA damage checkpoint 1 (MDC1) is a novel estrogen receptor co-regulator in invasive lobular carcinoma of the breast

E. K. Bordeaux, J. L. Sottnik, S. Mehrotra, S. E. Ferrara, A. E. Goodspeed, J. C. Costello, M. J. Sikora

This study identifies MDC1 as a novel ER co-regulator in ILC that promotes ER-driven proliferation and anti-estrogen resistance.

bioRxiv · Dec 16, 2020Cancer Biology