R. Fu

Dissecting cell-free DNA fragmentation variation in tumors using cell line-derived xenograft mouse

The paper investigates cfDNA fragmentation patterns in tumor models to distinguish between non-tumor cfDNA and ctDNA, finding differences in fragment length and site-specific variation.

Multi-pronged analysis of pediatric low-grade glioma reveals a unique tumor microenvironment associated with BRAF alterations

This study uses multi-omics approaches to analyze pediatric low-grade glioma and identifies immune-related differences linked to BRAF mutations.

SKP2-mediated FBXO2 proteasomal degradation drives hepatocellular carcinoma progression via stabilizing Hsp47

The paper shows that loss of FBXO2 promotes hepatocellular carcinoma by stabilizing Hsp47 through SKP2-mediated proteasomal degradation.

AP-1 regulates heterogeneous cellular dormancy in TNBC

The paper identifies heterogeneous subpopulations of slow-cycling cells in TNBC and shows AP-1, particularly the JunB subunit, regulates dormancy and drug resistance.

Co-regulator activity of Mediator of DNA Damage Checkpoint 1 (MDC1) is associated with DNA repair dysfunction and PARP inhibitor sensitivity in lobular carcinoma of the breast

This study identifies MDC1's role in ER co-regulation and DNA repair dysfunction in ILC, linking it to PARP inhibitor sensitivity.

3D-printed, Citrate-based Bioresorbable Vascular Scaffolds for Coronary Artery Angioplasty

This paper develops a drug-eluting bioresorbable vascular scaffold with reduced strut thickness and controlled drug release, showing comparable pre-clinical performance to metallic stents.

Investigation of 3D Printed Bioresorbable Vascular Scaffold Crimping Behavior

The paper develops a simulation tool using ABAQUS to analyze the crimping behavior of 3D-printed bioresorbable vascular scaffolds, enabling faster design evaluation than experimental testing.

Global and local adaptation to aridity in a desert plant Gymnocarpos przewalskii

This study identifies genes involved in global and local adaptation to aridity in Gymnocarpos przewalskii, finding limited overlap between the two processes.

On-Pathway Oligomer of Human Islet Amyloid Polypeptide Induced and Stabilized by Mechanical Rotation During MAS NMR

This study produces stable, on-pathway oligomers of hIAPP using mechanical rotation during MAS NMR, showing sensitivity to sample conditions and potential for studying other aggregating systems.

Dimeric Transmembrane Structure of the SARS-CoV-2 E Protein

The paper determines the dimeric structure of the SARS-CoV-2 E protein using NMR and simulations, identifying a hydrophobic pore and potential drug-binding site.

ANKRD49 promotes the metastasis of NCI-H1299 and NCI-H1703 cells via activating JNK-ATF2/c-Jun-MMP-2/9 axis

This study shows ANKRD49 promotes metastasis in NSCLC cells by activating the JNK-ATF2/c-Jun-MMP-2/9 pathway.

Kinetics and efficacy of antibody drug conjugates in 3D tumour models

This study evaluates ADC efficacy in 3D tumor models, finding that spheroids are less sensitive to ADCs than monolayers, but ADCs can fully penetrate within 24h.

Development and optimisation of cationic lipid nanoparticles for mRNA delivery

This study develops and optimises cationic lipid nanoparticles for mRNA delivery in ovarian cancer cells, achieving 62% encapsulation efficiency and 9.4-fold transfection luminescence.

Intranasal delivery of NS1-deleted influenza virus vectored COVID-19 vaccine restrains the SARS-CoV-2 inflammatory response

This study evaluates an intranasal influenza-based vaccine against SARS-CoV-2 variants, showing it reduces inflammatory response and tissue damage through local immunity.

Direct N-Me Aziridination Reaction Enables Pinpointing C=C Bonds in Lipids with Mass Spectrometry

This paper introduces a chemical derivatization method using N-Me aziridination to precisely identify C=C bond positions in lipids via mass spectrometry.

Collagen remodeling dictates pancreatic cancer bioenergetics and outcome through DDR1 activation or degradation

This study shows that collagen remodeling via MMP cleavage affects pancreatic cancer bioenergetics and outcome through DDR1 activation or degradation, with distinct impacts on tumor growth and survival.

Spatial transcriptomic analysis of childhood ependymoma implicates unresolved wound healing as a driver of tumor progression

This study uses spatial transcriptomics to analyze childhood ependymoma, revealing unresolved wound healing as a driver of tumor progression through distinct cellular interactions and states.

Inhibition of aryl hydrocarbon receptor signaling promotes the terminal differentiation of human erythrocytes

This study shows that inhibiting AHR signaling enhances terminal differentiation of human erythrocytes by promoting F-actin remodeling and cytoskeleton maturation.

Molecular tracking devices quantify antigen distribution and archiving in the lymph node

The paper develops molecular tracking devices to study antigen distribution and archiving in lymph nodes, revealing antigen retention in LECs and stromal cells via caveolar endocytosis.

Histone deacetylase inhibitor givinostat attenuates nonalcoholic steatohepatitis and liver fibrosis

This study evaluates givinostat's efficacy in treating NASH by reducing inflammation and fibrosis in mouse models.

Exploring the Mechanism of Olfactory Recognition at the Initial Stage by Modeling the Emission Spectrum of Electron Transfer

The paper models electron transfer in olfaction to explain odor recognition, showing emission spectra can distinguish similar odors and explain isotope effects.

Gene-centric intra- and inter-clade recombination in a context of Escherichia coli subpopulations

The paper analyzes recombination patterns in Escherichia coli genomes to show extensive intra-clade recombination and reduced inter-clade recombination, establishing genetic barriers between subpopulations.