Author

Z. Fleischmann

Northeastern University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Evolutionary Biology· 2 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:statistical model· 4 Assay:whole-genome sequencing· 3 Assay:bulk RNA-seq· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:differential expression· 2 Assay:DNA methylation· 2 Research Focus:drug response / drug discovery· 2

Frequent Co-Authors

K. Gunbin· 3 shared K. PopadiniD· 3 shared K. Khrapko· 2 shared M. Franco· 2 shared S. Annis· 2 shared A. A. Mikhailova· 1 shared A. Agranovsky· 1 shared A. G. MikhaylovaiD· 1 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersEvolutionary Biology

K. Gunbin

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Co-regulator activity of Mediator of DNA Damage Checkpoint 1 (MDC1) is associated with DNA repair dysfunction and PARP inhibitor sensitivity in lobular carcinoma of the breast

J. L. Sottnik, M. T. Shackleford, C. S. Nesiba, A. L. Richer, Z. Fleischmann, J. M. Swartz, C. E. Rowland, M. Musick, R. Fu, L. R. Myler, P. L. Opresko, S. Mehrotra, E. S. Sokol, J. R. Hesselberth, J. R. Diamond, M. J. Sikora

This study identifies MDC1's role in ER co-regulation and DNA repair dysfunction in ILC, linking it to PARP inhibitor sensitivity.

bioRxiv · Oct 29, 2023Cancer Biology

Direction mutation pressure of SARS-CoV-2 helps to understand the past and predict the future evolution: C>U and G>U biased mutagenesis forces the majority of amino-acid substitutions to be from CG-rich losers to U-rich gainers

A. Voronka, B. Efimenko, S. Oreshkov, M. Franco, Z. Fleischmann, V. Yurov, A. Trufanova, V. Timonina, N. Ree, A. Zalevsky, E. Penfrat, T. Junier, A. Agranovsky, K. Khrapko, K. Gunbin, , K. Popadin

The paper analyzes SARS-CoV-2 mutagenesis, showing C>U and G>U biases drive amino-acid substitutions from CG-rich losers to U-rich gainers, with implications for vaccine design.

bioRxiv · Aug 22, 2022 · PreprintEvolutionary Biology

Integrative analysis of a large real-world cohort of small cell lung cancer identifies distinct genetic subtypes and insights into histological transformation

S. Sivakumar, J. A. Moore, M. Montesion, R. Sharaf, D. I. Lin, Z. Fleischmann, E. M. Ebot, J. Newberg, J. M. Mills, P. S. Hedge, G. M. Frampton, J. Sage, C. M. Lovly

This study analyzes 3,600 SCLC cases to identify new genetic subtypes and insights into histological transformation, revealing associations between genetic alterations and survival outcomes.

bioRxiv · Jul 27, 2022Cancer Biology

Mammalian mitochondrial mutational spectrum as a hallmark of cellular and organismal aging.

A. G. Mikhaylova, A. A. Mikhailova, K. Ushakova, E.O. Tretiakov, V. Shamansky, Andrey A. Yurchenko, M. Zazhytska, E. Zdobnov, Vsevolod J. Makeev, Valerian A. Yurov, M. Tanaka, Irina S. Gostimskaya, Z. Fleischmann, S. Annis, M. Franco, , K. Popadin

The paper investigates mtDNA mutational spectra across species and tissues, finding a correlation between AH>GH substitutions and longevity, suggesting it as a potential oxidative damage signature in mtDNA.

bioRxiv · Apr 27, 2021 · PreprintGenomics

Mitochondrial pseudogenes suggest repeated inter-species hybridization in hominid evolution.

K. Popadin, K. Gunbin, L. Peshkin, S. Annis, Z. Fleischmann, G. Kraytsberg, N. Markuzon, R. R. Ackermann, K. Khrapko

The paper identifies mitochondrial pseudogenes in hominids, suggesting repeated inter-species hybridization during human evolution.

bioRxiv · Oct 19, 2017Evolutionary Biology