Molecular mechanism of α-synuclein aggregation on lipid membranes revealed.
A. J. Dear, X. Teng, S. R. Ball, J. Lewin, R. I. Horne, D. Clow, N. Harper, K. Yahya, T. C. Michaels, S. Linse, T. P. Knowles, X. Yang, S. C. Brewerton, J. Thomson, J. Habchi, G. Meisl
This study reveals that lipids promote α-synuclein aggregation by enabling elongation, using a kinetic model to describe the co-aggregation process in vitro.
bioRxiv · Oct 20, 2023Biophysics