X. Yang

J chain dictates the recognition of IgA by FcRL4

The paper determines that FcRL4 recognizes IgA via the J chain, revealing structural and functional differences in IgA receptor interactions.

Synergistic Multi-Enzyme Cascades Assembled on Modular Protein Scaffolds for Efficient PET Biorecycling

This paper develops a modular protein scaffold system to assemble multiple enzymes for efficient PET biorecycling, achieving higher conversion rates than previous systems.

Population responses to environmental stochasticity are primarily driven by survival-reproduction trade-offs and mediated by aridity

The paper uses Bayesian models to show that population responses to environmental stochasticity vary widely and are driven by survival-reproduction trade-offs and aridity.

Size evolution of gigantic genomes suggests stochastic outcomes of transposable element/host silencing interactions

The paper examines TE/host interactions in salamander genomes and finds no correlation between genome size and TE deletion rates or suppression, suggesting stochastic TE accumulation in gigantic genomes.

Linalool fumigation improves mating competitiveness of males for population suppression of the global fruit pest Cydia pomonella

This study finds that linalool fumigation improves mating competitiveness of X-ray-sterilized Cydia pomonella males, enhancing the effectiveness of sterile insect technique for population suppression.

DdmDE eliminates plasmid invasion by DNA-guided DNA targeting

This study elucidates the mechanism of the DdmDE system in eliminating plasmids through DNA-guided targeting and cleavage.

Moderate Cold Stress Enhance Drought Resistance through CCA1 via -an ABA- independent Pathway

This study shows that moderate cold stress improves Arabidopsis drought tolerance through the CCA1 pathway, independent of ABA, by promoting stomatal closure and proline accumulation before drought occurs.

Clathrin-associated carriers enable recycling through a kiss-and-run mechanism

The paper identifies a novel endocytic recycling mechanism called CARP, which involves clathrin-associated carriers undergoing partial membrane fusion and release.

Basal Cambrian soft-bodied segmented bilaterians preserved as microbial pseudomorphs

This study identifies microbial pseudomorphs as the earliest three-dimensional body fossils of segmented bilaterians from the basal Cambrian, revealing a diversified bilaterian world.

Chromosome-level genome assembly of autotetraploid Selenicereus megalanthus and gaining genomic insights into the evolution of trait patterning in diploid and polyploid pitaya species

Improving the reliability of T2 measurement in magnetic resonance imaging

This study investigates factors affecting T2 measurement reliability in MRI using Monte Carlo simulations and finds that SNR, TE range, and repetition number influence reproducibility.

Enrichment of glycoRNAs using galactose oxidase, hydrazide chemistry, and glycosidase digestion

The paper develops and optimizes methods to enrich and identify glycoRNAs, demonstrating efficient digestion and preservation techniques for studying their role in immune responses and disease.

Transcriptome-wide mapping of small-molecule RNA-binding sites in live cells

This paper describes a method to map small-molecule RNA-binding sites in live cells and identifies their targets and binding sites.

E. coli FtsN coordinates synthesis and degradation of septal peptidoglycan by partitioning between a synthesis track and a denuded glycan track

Spatiotemporal control of subcellular O-GlcNAc signaling using Opto-OGT

This study introduces Opto-OGT, an optogenetic tool to control O-GlcNAc modification, showing its ability to modulate mTORC and AKT signaling in response to light.

Targeting LxCxE cleft pocket of retinoblastoma protein in M2 macrophages inhibits ovarian cancer progression

This study shows targeting the LxCxE cleft pocket of Rb in M2 macrophages inhibits ovarian cancer progression by reducing immunosuppressive TAMs and enhancing T cell infiltration.

Physiological Processing of Aversiveness in the Mind's Ear: Comparing Audiovisual, Auditory and Imagined Auditory Affective Stimuli

The paper compares physiological responses to aversive and nonaversive audiovisual, auditory, and imagined auditory stimuli, finding consistent EMGc differentiation across modalities.

CCR7+ Dendritic Cells Define a Type 17 Module in Psoriasis

The paper identifies CCR7+ dendritic cells as the primary source of IL-23 in psoriasis, linking them to type 17 inflammation and relapse.

CRISPR screens reveal convergent targeting strategies against evolutionarily distinct chemoresistance in cancer

This study identifies convergent therapeutic targets for chemoresistance in cancer using CRISPR screens across multiple drug conditions and cancer models.

The nuclear sulfenome of Arabidopsis: spotlight on histone acetyltransferase GCN5 regulation through functional thiols

This study identifies 225 redox-active nuclear proteins in Arabidopsis, including GCN5, modified by sulfenylation under oxidative stress, revealing their functional impact on protein interactions.

Genetic purging of strongly deleterious mutations underlies black-necked crane's unusual escape from an extinction vortex

This study shows black-necked cranes rapidly recovered from a population bottleneck through genetic purging of deleterious mutations, escaping an extinction vortex.

Artificial Intelligence-Enabled AlphaFold II Pipeline Guides Functional Fluorescence Labeling of Tubulin Across Species

The paper develops an AI-driven method to label tubulin isotypes in vivo across species, enabling precise visualization of microtubule dynamics and pathogenic variants without disrupting cellular processes.

Dysfunctional β-cell longevity in diabetes relies on high energy conservation and positive epistasis

The paper identifies PFKFB3-expressing dysfunctional β-cells in T2D, showing their survival via positive epistasis and reduced clearance, and demonstrates PFKFB3 inhibition restores glucose tolerance in mice.

Deep learning based genomic breeding of pest-resistant grapevine

This study uses deep learning and genome-wide association studies to identify pest-resistant genes in grapevine, achieving high accuracy in predicting pest damage.

An optimized somatic embryo transformation system assisted homozygous edited rubber tree generation method mediated by CRISPR/Cas9

This study develops a CRISPR/Cas9-based method to generate homozygous edited rubber tree plants by optimizing somatic embryo transformation and subculture procedures.

Prenatal Exposure to Environmentally Relevant Low Dosage Dibutyl Phthalate Reduces Placental Efficiency in CD-1 Mice

This study shows that low-dose prenatal DBP exposure reduces placental efficiency in female fetuses but not males in CD-1 mice.

PathEX: Make Good Choice for Whole Slide Image Extraction

PathEX improves tile image extraction from whole slide images by adjusting IoT and BoT parameters to focus on annotated regions' boundaries and exclude blank tiles.

Feed-forward stimulation of CAMK2 by the oncogenic pseudokinase PEAK1 generates a therapeutically "actionable" signalling axis in triple negative breast cancer

This study identifies a novel feed-forward signalling axis between PEAK1 and CAMK2 in TNBC, showing that targeting CAMK2 can inhibit PEAK1-driven oncogenic processes.

ATP13A1 engages GET3 to facilitate substrate-specific translocation

The paper shows ATP13A1 uses GET3 to translocate cleaved signal sequences to the ER in a substrate-specific manner, ensuring efficient and accurate protein localization.

Sarbecovirus RBD indels and specific residues dictating ACE2 multi-species adaptiveness

This study identifies RBM indel types in sarbecoviruses and their impact on ACE2 receptor usage across species, revealing how specific residues and structural features influence tropism and adaptiveness.