The interferon-rich skin environment regulates Langerhans cell ADAM17 to promote photosensitivity in lupus
T. M. Li, V. Zyulina, E. S. Seltzer, M. Dacic, Y. Chinenov, A. Daamen, K. R. Veiga, N. Schwartz, D. J. Oliver, J. Lora, A. Jabbari, Y. Liu, W. D. Shipman, W. G. Ambler, S. F. Taber, , T. T. Lu
This study shows that IFN-I in lupus skin reduces Langerhans cell ADAM17 activity, leading to increased photosensitivity, and that anti-IFNAR treatment restores ADAM17 function and reduces photosensitivity.
bioRxiv · Aug 18, 2021Immunology