TRIB3 silencing promotes the downregulation of Akt pathway and PAX3-FOXO1 in high-risk rhabdomyosarcoma
G. O. Gallo-Oller, G. Pons, J. Sansa-Girona, N. Navarro, P. Zarzosa, L. Garcia-Gilabert, P. Cabre Fernandez, G. Guillen Barrieza, L. Valero-Arrese, M. F. Segura, J. M. Lizcano, J. Sanchez de Toledo, L. Moreno, S. Gallego, J. Roma
This study shows TRIB3 silencing reduces Akt pathway activity and PAX3-FOXO1 levels in high-risk rhabdomyosarcoma, leading to decreased tumor growth and improved survival.
bioRxiv · Dec 1, 2023Cancer Biology