X. Dolcet

In vivo intra-uterine delivery of TAT-fused Cre recombinase and CRISPR/Cas9 editing unveil histopathology of Pten/p53-deficient endometrial cancers.

This study shows that simultaneous deletion of Pten and p53 in endometrial epithelial cells leads to epithelial to mesenchymal transition and the formation of uterine carcinosarcomas in vivo.

Transient and DNA-free in vivo CRISPR/Cas9 genome edition for flexible modelling of endometrial carcinogenesis

This paper develops an in vivo CRISPR/Cas9 system for generating mouse models of endometrial cancer by targeting tumor suppressor genes and demonstrating tumor development and heterogeneity.

The ERK5/NF-κB signaling pathway targets endometrial cancer proliferation and survival

This study identifies the ERK5/NF-κB pathway as a driver of endometrial cancer proliferation and survival, showing that its inhibition sensitizes tumors to chemotherapy and reduces xenograft growth.