Cell BiologybioRxiv
Genome-wide CRISPR screens reveal multitiered mechanisms through which mTORC1 senses mitochondrial dysfunction
K. J. Condon, J. M. Orozco, C. H. Adelmann…·D. M. Sabatini
This study uses CRISPR screens to identify genes regulating mTORC1 activity and reveals that mitochondrial dysfunction is sensed through AMPK and HRI signaling pathways.
DOI 10.1073/pnas.2022120118